Dr Anthony Holmes


Head – Technology development



Email address


Anthony leads our technology development programmes and is a member of the Innovation and Translation Group.

View Anthony's Office-led projects

Other programmes of work

Technology partnering hub CRACK IT Solutions

Advancing the development and application of non-animal technologies - NATs

NC3Rs publications

Holmes A, Charlton A, Derby B, Ewart L, Scott A, Shu W (2017) Rising to the challenge: applying biofabrication approaches for better drug and chemical product development. Biofabrication doi: 10.1088/1758-5090/aa7bbd

Holmes A, Bonner, F, Jones D (2015) Assessing drug safety in human tissues - what are the barriers? Nature Reviews Drug Discovery doi: 10.1038/nrd4662

Barnes P.J, Bonini S, Seeger W, Belvisi MG, Ward B, Holmes A. (2015) Barriers to new drug development in respiratory disease. Eur Respir J 45: 1197-207 doi: 10.1183/09031936.00007915

Edwards J, Belvisi M,Dahlen SE, Holgate S, Holmes A. (2015) Human tissue models for a human disease: what are the barriers? Thorax 70: 695-7 doi:10.1136/thoraxjnl-2014-206648

Percie du Sert N, Holmes A.M, Wallis M, Andrews PL. (2012) Predicting the emetic liability of novel chemical entities: a comparative study. British Journal of Pharmacology 165: 1848-1867 doi: 10.1111/j.1476-5381.2011.01669.x

Holmes A.M,  Solari R, Holgate S.T, (2011) Animal models of asthma: value, limitations and opportunities for alternative approaches.Drug Discovery Today 16: 659-670 doi: 10.1016/j.drudis.2011.05.014

Holmes A.M, Creton S, Chapman K. (2010) Working in partnership to advance the 3Rs in toxicity testing Toxicology 12: 14-19 doi:10.1016/j.tox.2009.11.006

Westmoreland C, Holmes A.M,  (2009) Assuring consumer safety without animals: Applications for tissue engineering Organogenesis 5: 67-72. No doi, click to view.

Holmes A.M, Rudd JA, Tattersall FD, Q Aziz, Andrews PLR. (2009) Opportunities for the replacement of animals in the study of nausea and vomiting British Journal of Pharmacology 157: 865-80 doi: 10.1111/j.1476-5381.2009.00176.x

Holmes A, Brown R, Shakesheff K (2009) Engineering tissue alternatives to animals: applying tissue engineering to basic research and safety testing Regenerative Medicine 4: 579-592 doi: 10.2217/rme.09.26

NC3Rs blogs:

For additional publications, see Ant's ResearchGate profile.


PhD, Biology
University of Cambridge, 2001 - 2004
The ins and outs of calcium signalling: regulation of calcium entry and release in electrically non-excitable cells.