In this section
- 3Rs research funding
- Funded 3Rs research
- Funding in 2009
- Funding in 2008
- Funding in 2007
- Funding in 2006
- Funding in 2005
- Funding in 2004
- Professor Aziz, Queen Mary, University of London
- Dr Michael Emerson, Imperial College London
- Dr Berthold Gottgens, University of Cambridge
- Dr Majid Hafezparast, University of Sussex
- Dr Susan Jobling, Brunel University
- Professor Mark Lewis, University of Bedfordshire
- Prof Mackenzie, Barts and The London School of M&D
- Dr Kevin Moffat, University of Warwick
- Professor Hugh Perry, University of Southampton
- Dr Johnny Roughan, Newcastle University
- Dr Vasanta Subramanian, University of Bath
- Professor Susan Watson, University of Nottingham
- Dr R Williams, Royal Holloway University of London
- Professor Sue Barnett, University of Glasgow
- Professor Andrew Cossins, University of Liverpool
- Dr Atticus Hainsworth, St George's London
- Dr Ioanna Katsiadaki, Cefas
- Professor Robert Newbold, Brunel University
- Dr N G Coldham, Veterinary Laboratories Agency
- Professor D E Davies, University of Southampton
- Professor J A Davies, University of Edinburgh
- Professor C R Wolf, University of Dundee
- Dr A J Grierson, University of Sheffield
- Dr M Guille, University of Portsmouth
- Dr W Hope, University of Manchester
- Dr P Jones, Hutchison/MRC Research Centre
- Professor P M Jones, King's College London
- Dr A MacNicoll, Central Science Laboratory
- Dr G Woodhall, Aston University
- Dr Fullwood, Lancaster University
- Dr Emerson, Imperial College London
- Professor Perry, University of Southampton
- Professor Baker, University of Newcastle
- Dr Walmsley, University of Manchester
- Dr Xing, NIBSC
- Professor Harding, Imperial College London
- Dr Thompson, Central Science Laboratory
- Dr Sloan, Cardiff University
- Professor Thomas, Cardiff University
- Professor Wolf, CXR Biosciences Ltd
- Dr Tucker, University of Cambridge
- Dr Turrell, Fisheries Research Services
- Dr Redhead, Intervet UK Ltd
- Dr Smith, University of Sheffield
- Professor Ward, Keele University
- Professor Lemon, University College London
- Dr Roughan, University of Newcastle
- Professor Bibby, University of Bradford
- Professor Nicol, University of Bristol
- Dr Keith Redhead, Intervet UK Ltd
- Dr Paul Simons, University College London
- Professor Phil Stephens, Cardiff University
- Professor Sriskandan, Imperial College London
- Dr Jun Zou, University of Aberdeen
- Professor Baker, Queen Mary, University of London
- Professor Barclay, Imperial College London
- Dr Brennan, Queen Mary, University of London
- Dr Chesler, Institute of Cancer Research
- Professor Harding, Imperial College London
- Professor Hogstrand, King's College Londo
- Dr Hohenstein, MRC Human Genetics Unit
- Professor Howard, University of Ulster
- Dr Roland Jones, University of Bath
- Dr Nassar, University of Sheffield
- Dr Sansom, University of Glasgow
- Professor Secombes, University of Aberdeen
- Dr Sesardic, NIBSC
- Studentships
- Funded studentships
- Strategic awards
- NC3Rs / LASA Small Awards Scheme
- NC3Rs transfer to Je-S
|
Dr Johnny Roughan and Professor Paul Flecknell, Newcastle University
Assessing the welfare of mice used in cancer research
Abstract of research Cancer research in the UK involves nearly 400,000 animals per year, of which 96% are mice. Many of these develop tumours that are assumed to cause pain and/or distress, so guidelines have been developed with the aim of removing animals from studies before any suffering occurs. However, these guidelines do not include objective assessments of animal welfare. This project aims to determine which cancer models cause the most pain and at what stage of tumour development it occurs. This could result in certain tumour types being avoided and, where this is not possible, the development of more relevant guidelines for refining humane endpoints. Although previous NC3Rs funded work indicated that mice with bladder cancer experienced pain, individual variations in tumour growth rate made it impossible to refine endpoints. This new research will more accurately establish the relationship between cancer development and the onset of pain in three common mouse cancer models. The project will determine whether new methodologies can be used to assess the subjective experiences of mice with cancer and whether current endpoint estimates are appropriate. The methods used to determine whether mice feel cancer pain will be the conditioned place preference paradigm (CPP) and conditional drug discrimination. In CPP, if the mouse shows a preference for an environment where they were previously exposed to an analgesic (e.g. morphine), and that preference increases over time, it can be inferred that they feel more pain as the tumour develops. In the drug discrimination studies, mice are given either an analgesic or placebo and perform a task to obtain a food reward. Changes in task success rate can then be used to monitor whether they are feeling pain. These measures of the subjective state of the animal will then be correlated with changes in behaviour, peripheral sensitisation, and measures of tumour growth to give a clearer picture of pain caused by different tumour types. More broadly this work will establish new methods for assessing the welfare consequences of other potentially painful procedures applied to laboratory rodents.
|
|
Return to top
