In this section
- 3Rs research funding
- Funded 3Rs research
- Funding in 2009
- Funding in 2008
- Funding in 2007
- Funding in 2006
- Funding in 2005
- Funding in 2004
- Professor Aziz, Queen Mary, University of London
- Dr Michael Emerson, Imperial College London
- Dr Berthold Gottgens, University of Cambridge
- Dr Majid Hafezparast, University of Sussex
- Dr Susan Jobling, Brunel University
- Professor Mark Lewis, University of Bedfordshire
- Prof Mackenzie, Barts and The London School of M&D
- Dr Kevin Moffat, University of Warwick
- Professor Hugh Perry, University of Southampton
- Dr Johnny Roughan, Newcastle University
- Dr Vasanta Subramanian, University of Bath
- Professor Susan Watson, University of Nottingham
- Dr R Williams, Royal Holloway University of London
- Professor Sue Barnett, University of Glasgow
- Professor Andrew Cossins, University of Liverpool
- Dr Atticus Hainsworth, St George's London
- Dr Ioanna Katsiadaki, Cefas
- Professor Robert Newbold, Brunel University
- Dr N G Coldham, Veterinary Laboratories Agency
- Professor D E Davies, University of Southampton
- Professor J A Davies, University of Edinburgh
- Professor C R Wolf, University of Dundee
- Dr A J Grierson, University of Sheffield
- Dr M Guille, University of Portsmouth
- Dr W Hope, University of Manchester
- Dr P Jones, Hutchison/MRC Research Centre
- Professor P M Jones, King's College London
- Dr A MacNicoll, Central Science Laboratory
- Dr G Woodhall, Aston University
- Dr Fullwood, Lancaster University
- Dr Emerson, Imperial College London
- Professor Perry, University of Southampton
- Professor Baker, University of Newcastle
- Dr Walmsley, University of Manchester
- Dr Xing, NIBSC
- Professor Harding, Imperial College London
- Dr Thompson, Central Science Laboratory
- Dr Sloan, Cardiff University
- Professor Thomas, Cardiff University
- Professor Wolf, CXR Biosciences Ltd
- Dr Tucker, University of Cambridge
- Dr Turrell, Fisheries Research Services
- Dr Redhead, Intervet UK Ltd
- Dr Smith, University of Sheffield
- Professor Ward, Keele University
- Professor Lemon, University College London
- Dr Roughan, University of Newcastle
- Professor Bibby, University of Bradford
- Professor Nicol, University of Bristol
- Dr Keith Redhead, Intervet UK Ltd
- Dr Paul Simons, University College London
- Professor Phil Stephens, Cardiff University
- Professor Sriskandan, Imperial College London
- Dr Jun Zou, University of Aberdeen
- Professor Baker, Queen Mary, University of London
- Professor Barclay, Imperial College London
- Dr Brennan, Queen Mary, University of London
- Dr Chesler, Institute of Cancer Research
- Professor Harding, Imperial College London
- Professor Hogstrand, King's College Londo
- Dr Hohenstein, MRC Human Genetics Unit
- Professor Howard, University of Ulster
- Dr Roland Jones, University of Bath
- Dr Nassar, University of Sheffield
- Dr Sansom, University of Glasgow
- Professor Secombes, University of Aberdeen
- Dr Sesardic, NIBSC
- Studentships
- Funded studentships
- Strategic awards
- NC3Rs / LASA Small Awards Scheme
- NC3Rs transfer to Je-S
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Dr Roughan, University of Newcastle
Neoplasia and pain in laboratory animals Aims Tumour-bearing laboratory animals, mice in particular, are widely used by scientists as model systems for the study of cancer and therapeutic advances in its treatment. However, no systematic and objective studies have been undertaken to investigate tumour-induced pain in laboratory animals. The proposed research aims to evaluate tumour-induced pain in rodents, and to develop a practical and reliable system for pain measurement. Methods Specifically, the research will ask the following questions:
1. Are animal tumour models associated with host pain?
2. Can host pain be detected by behaviour analysis?
3. Can behavioural changes that indicate pain be attenuated by analgesics?
4. Are tumour growth and behavioural changes associated with the development of hyperalgesia and allodynia?
5. Is tumour growth associated with increased self-administration of analgesics? Different models will be used to define the circumstances under-which pain could occur in tumour-bearing animals. Using an approach already shown to be successful for assessing post-operative pain in rodents, a reliable system that will detect pain and other tumour-induced adverse effects, will be developed. This assessment system will then be used to evaluate pain severity and duration, and to develop strategies to prevent and alleviate pain, and other adverse effects, in animals used in cancer research. Implications for the 3Rs One of the challenges in research involving animals with neoplasia is to accurately determine appropriate humane end-points. Improving the assessment of tumour-induced pain will have a positive impact on the welfare of a large number of animals. The results of this study will be important for future research into identifying tumour-induced pain, the development of pain alleviation strategies in other rodent species, and attempts to refine the use of animals in cancer research.
Publications - Roughan JV, Sufka K, Coulter CA, Flecknell PA The conditioned place preference paradigm for assessing cancer pain in mice. European Journal of Pain, In press
- Roughan JV, Wright-Williams SL and Flecknell PA (2009) Automated analysis of post-operative behaviour: assessment of HomeCageScan as a novel method to rapidly identify pain and analgesic effects in mice. Laboratory Animals 43 (1), 17-26
Read the abstract - Wright-Williams SL, Courade JP, Richardson CA, Roughan JV and Flecknell PA (2007) Effects of vasectomy surgery and meloxicam treatment on faecal corticosterone levels and behaviour in two strains of laboratory mouse. Pain 130 (1-2), 108-118
Read the abstract
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