In this section
- 3Rs research funding
- Funded 3Rs research
- Funding in 2009
- Funding in 2008
- Funding in 2007
- Funding in 2006
- Funding in 2005
- Funding in 2004
- Professor Aziz, Queen Mary, University of London
- Dr Michael Emerson, Imperial College London
- Dr Berthold Gottgens, University of Cambridge
- Dr Majid Hafezparast, University of Sussex
- Dr Susan Jobling, Brunel University
- Professor Mark Lewis, University of Bedfordshire
- Prof Mackenzie, Barts and The London School of M&D
- Dr Kevin Moffat, University of Warwick
- Professor Hugh Perry, University of Southampton
- Dr Johnny Roughan, Newcastle University
- Dr Vasanta Subramanian, University of Bath
- Professor Susan Watson, University of Nottingham
- Dr R Williams, Royal Holloway University of London
- Professor Sue Barnett, University of Glasgow
- Professor Andrew Cossins, University of Liverpool
- Dr Atticus Hainsworth, St George's London
- Dr Ioanna Katsiadaki, Cefas
- Professor Robert Newbold, Brunel University
- Dr N G Coldham, Veterinary Laboratories Agency
- Professor D E Davies, University of Southampton
- Professor J A Davies, University of Edinburgh
- Professor C R Wolf, University of Dundee
- Dr A J Grierson, University of Sheffield
- Dr M Guille, University of Portsmouth
- Dr W Hope, University of Manchester
- Dr P Jones, Hutchison/MRC Research Centre
- Professor P M Jones, King's College London
- Dr A MacNicoll, Central Science Laboratory
- Dr G Woodhall, Aston University
- Dr Fullwood, Lancaster University
- Dr Emerson, Imperial College London
- Professor Perry, University of Southampton
- Professor Baker, University of Newcastle
- Dr Walmsley, University of Manchester
- Dr Xing, NIBSC
- Professor Harding, Imperial College London
- Dr Thompson, Central Science Laboratory
- Dr Sloan, Cardiff University
- Professor Thomas, Cardiff University
- Professor Wolf, CXR Biosciences Ltd
- Dr Tucker, University of Cambridge
- Dr Turrell, Fisheries Research Services
- Dr Redhead, Intervet UK Ltd
- Dr Smith, University of Sheffield
- Professor Ward, Keele University
- Professor Lemon, University College London
- Dr Roughan, University of Newcastle
- Professor Bibby, University of Bradford
- Professor Nicol, University of Bristol
- Dr Keith Redhead, Intervet UK Ltd
- Dr Paul Simons, University College London
- Professor Phil Stephens, Cardiff University
- Professor Sriskandan, Imperial College London
- Dr Jun Zou, University of Aberdeen
- Professor Baker, Queen Mary, University of London
- Professor Barclay, Imperial College London
- Dr Brennan, Queen Mary, University of London
- Dr Chesler, Institute of Cancer Research
- Professor Harding, Imperial College London
- Professor Hogstrand, King's College Londo
- Dr Hohenstein, MRC Human Genetics Unit
- Professor Howard, University of Ulster
- Dr Roland Jones, University of Bath
- Dr Nassar, University of Sheffield
- Dr Sansom, University of Glasgow
- Professor Secombes, University of Aberdeen
- Dr Sesardic, NIBSC
- Studentships
- Funded studentships
- Strategic awards
- NC3Rs / LASA Small Awards Scheme
- NC3Rs transfer to Je-S
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Dr Fullwood, Lancaster University
Development of an in vitro model for the anterior region of the eye Aims The objective is to develop an in vitro model of the front part of eye (cornea) which will replace a significant number of procedures carried out on live animal eyes worldwide. Live animals are currently used for many investigations on the eye. These include research into diseases causing blindness, such as keratoconus or Fuch's dystrophy, and the tests carried out by commercial companies to test new substances. Method In the proposed model, the cornea of cow eyes that are a by-product of the meat industry and would otherwise be thrown away, are maintained in a special chamber. They are supplied with nutrients which allow them to remain alive for several weeks. The model will be rigorously evaluated over a period of 30 days and the evaluation will include all cell types in the cornea. The transparency, thickness and permeability of the cornea will also be monitored and microscopy will be used to evaluate the fine structure of the cells. The results will be compared with currently available information on both human and animal corneas. Implications for the 3Rs It is intended that the model will be used for basic corneal research, medical corneal research and for commercial applications including toxicological testing. It is anticipated that the model will replace many procedures currently carried out on live animals. Publications - Zhao B, Cooper LJ, Brahma A, MacNeil S, Rimmer S & Fullwood NJ (2006) Development of a Three-Dimensional organ Culture Model for Corneal Wound Healing and Corneal Transplantation. Invest Ophthalmol Vis Sci 47 (7), 2840-6
Read the abstract - Zhao B, Allinson SL, Ma A, Bentley AJ, Martin FL & Fullwood NJ (2008) Targeted cornea limbal stem/progenitor cell transfection in an organ culture model. Invest Ophthalmol Vis Sci 49 (8), 3395-3401
Read the abstract - Zhao B, Ma A, Martin FL & Fullwood NJ (2009) An investigation into corneal alkali burns using an organ culture model. Cornea 28 (5), 541-546
Read the abstract - Zhao B, Ma A, Brahma A, MacNeil S, Martin FL, Rimmer S, Fullwood NJ. Corneal Epithelialisation on Surface-Modified Hydrogel Implants. Cornea, submitted 2009
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