In this section
- 3Rs research funding
- Funded 3Rs research
- Funding in 2009
- Funding in 2008
- Funding in 2007
- Funding in 2006
- Funding in 2005
- Funding in 2004
- Professor Aziz, Queen Mary, University of London
- Dr Michael Emerson, Imperial College London
- Dr Berthold Gottgens, University of Cambridge
- Dr Majid Hafezparast, University of Sussex
- Dr Susan Jobling, Brunel University
- Professor Mark Lewis, University of Bedfordshire
- Prof Mackenzie, Barts and The London School of M&D
- Dr Kevin Moffat, University of Warwick
- Professor Hugh Perry, University of Southampton
- Dr Johnny Roughan, Newcastle University
- Dr Vasanta Subramanian, University of Bath
- Professor Susan Watson, University of Nottingham
- Dr R Williams, Royal Holloway University of London
- Professor Sue Barnett, University of Glasgow
- Professor Andrew Cossins, University of Liverpool
- Dr Atticus Hainsworth, St George's London
- Dr Ioanna Katsiadaki, Cefas
- Professor Robert Newbold, Brunel University
- Dr N G Coldham, Veterinary Laboratories Agency
- Professor D E Davies, University of Southampton
- Professor J A Davies, University of Edinburgh
- Professor C R Wolf, University of Dundee
- Dr A J Grierson, University of Sheffield
- Dr M Guille, University of Portsmouth
- Dr W Hope, University of Manchester
- Dr P Jones, Hutchison/MRC Research Centre
- Professor P M Jones, King's College London
- Dr A MacNicoll, Central Science Laboratory
- Dr G Woodhall, Aston University
- Dr Fullwood, Lancaster University
- Dr Emerson, Imperial College London
- Professor Perry, University of Southampton
- Professor Baker, University of Newcastle
- Dr Walmsley, University of Manchester
- Dr Xing, NIBSC
- Professor Harding, Imperial College London
- Dr Thompson, Central Science Laboratory
- Dr Sloan, Cardiff University
- Professor Thomas, Cardiff University
- Professor Wolf, CXR Biosciences Ltd
- Dr Tucker, University of Cambridge
- Dr Turrell, Fisheries Research Services
- Dr Redhead, Intervet UK Ltd
- Dr Smith, University of Sheffield
- Professor Ward, Keele University
- Professor Lemon, University College London
- Dr Roughan, University of Newcastle
- Professor Bibby, University of Bradford
- Professor Nicol, University of Bristol
- Dr Keith Redhead, Intervet UK Ltd
- Dr Paul Simons, University College London
- Professor Phil Stephens, Cardiff University
- Professor Sriskandan, Imperial College London
- Dr Jun Zou, University of Aberdeen
- Professor Baker, Queen Mary, University of London
- Professor Barclay, Imperial College London
- Dr Brennan, Queen Mary, University of London
- Dr Chesler, Institute of Cancer Research
- Professor Harding, Imperial College London
- Professor Hogstrand, King's College Londo
- Dr Hohenstein, MRC Human Genetics Unit
- Professor Howard, University of Ulster
- Dr Roland Jones, University of Bath
- Dr Nassar, University of Sheffield
- Dr Sansom, University of Glasgow
- Professor Secombes, University of Aberdeen
- Dr Sesardic, NIBSC
- Studentships
- Funded studentships
- Strategic awards
- NC3Rs / LASA Small Awards Scheme
- NC3Rs transfer to Je-S
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Dr Emerson, Imperial College London
Refinement of a mouse model of pulmonary embolism Aims Blood clots can form in the large veins of the legs and are common in hospital patients, the elderly, and sometimes those sitting in economy class on long flights. Pulmonary embolism occurs when these clots detach and lodge in the lungs, causing heart and breathing problems, and often death. Animal tests are used to determine the causes of pulmonary embolism and to test potential new drug treatments. A commonly used test involves injecting substances into mice which cause clots to form, leading to paralysis and death, at a significant welfare cost to the animals. The aim of this project is to use an alternative model where the entire procedure is conducted in anaesthetised mice and neither paralysis nor death is induced. Method The clots which form in pulmonary embolism contain blood platelets, and the degree of embolism in an animal can be measured by radioactively labelling platelets. The same substances used to induce death from pulmonary embolism in the original model can be injected at lower doses in anaesthetised mice to induce trapping of labelled platelets in the lung. The levels of platelets in the lung can then be measured by placing detection probes over the chest. The effectiveness of new treatments is assessed by their ability to reduce platelet trapping and hence pulmonary embolism. Implications for the 3Rs The new model refines this area of research by inflicting considerably less pain and suffering to animals, because the procedure can be performed under general anaesthesia. Additionally, multiple responses can be obtained in the same mouse and more information is obtained in each experiment so that the number of animals used is reduced. Publications - Tymvios C, Moore C, Jones S, Solomon A, Sanz-Rosa D & Emerson M (2009) Platelet aggregation responses are critically regulated in vivo by endogenous nitric oxide but not endothelial nitric oxide synthase. British Journal of Pharmacology 158, 1735-1742
Read the abstract - Tymvios C, Jone S, Moore C, Pitchford SC, Page CP & Emerson M (2008) Real-time measurement of non-lethal platelet thromboembolic responses in the anaesthetized mouse. Thrombosis and Haemostasis 99 (2), 435-440
Read the abstract - Jones S, Tucker KL, Sage T, Kaiser WJ, Barrett NE, Lowry PJ, Zimmer A, Hunt SP, Emerson M, & Gibbins JM (2008) Peripheral tachykinins and the neurokinin receptor NK1 are required for platelet thrombus formation. Blood 111 (2), 605-12
Read the abstract
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