In this section
- 3Rs research funding
- Funded 3Rs research
- Funding in 2009
- Funding in 2008
- Funding in 2007
- Funding in 2006
- Funding in 2005
- Funding in 2004
- Professor Aziz, Queen Mary, University of London
- Dr Michael Emerson, Imperial College London
- Dr Berthold Gottgens, University of Cambridge
- Dr Majid Hafezparast, University of Sussex
- Dr Susan Jobling, Brunel University
- Professor Mark Lewis, University of Bedfordshire
- Prof Mackenzie, Barts and The London School of M&D
- Dr Kevin Moffat, University of Warwick
- Professor Hugh Perry, University of Southampton
- Dr Johnny Roughan, Newcastle University
- Dr Vasanta Subramanian, University of Bath
- Professor Susan Watson, University of Nottingham
- Dr R Williams, Royal Holloway University of London
- Professor Sue Barnett, University of Glasgow
- Professor Andrew Cossins, University of Liverpool
- Dr Atticus Hainsworth, St George's London
- Dr Ioanna Katsiadaki, Cefas
- Professor Robert Newbold, Brunel University
- Dr N G Coldham, Veterinary Laboratories Agency
- Professor D E Davies, University of Southampton
- Professor J A Davies, University of Edinburgh
- Professor C R Wolf, University of Dundee
- Dr A J Grierson, University of Sheffield
- Dr M Guille, University of Portsmouth
- Dr W Hope, University of Manchester
- Dr P Jones, Hutchison/MRC Research Centre
- Professor P M Jones, King's College London
- Dr A MacNicoll, Central Science Laboratory
- Dr G Woodhall, Aston University
- Dr Fullwood, Lancaster University
- Dr Emerson, Imperial College London
- Professor Perry, University of Southampton
- Professor Baker, University of Newcastle
- Dr Walmsley, University of Manchester
- Dr Xing, NIBSC
- Professor Harding, Imperial College London
- Dr Thompson, Central Science Laboratory
- Dr Sloan, Cardiff University
- Professor Thomas, Cardiff University
- Professor Wolf, CXR Biosciences Ltd
- Dr Tucker, University of Cambridge
- Dr Turrell, Fisheries Research Services
- Dr Redhead, Intervet UK Ltd
- Dr Smith, University of Sheffield
- Professor Ward, Keele University
- Professor Lemon, University College London
- Dr Roughan, University of Newcastle
- Professor Bibby, University of Bradford
- Professor Nicol, University of Bristol
- Dr Keith Redhead, Intervet UK Ltd
- Dr Paul Simons, University College London
- Professor Phil Stephens, Cardiff University
- Professor Sriskandan, Imperial College London
- Dr Jun Zou, University of Aberdeen
- Professor Baker, Queen Mary, University of London
- Professor Barclay, Imperial College London
- Dr Brennan, Queen Mary, University of London
- Dr Chesler, Institute of Cancer Research
- Professor Harding, Imperial College London
- Professor Hogstrand, King's College Londo
- Dr Hohenstein, MRC Human Genetics Unit
- Professor Howard, University of Ulster
- Dr Roland Jones, University of Bath
- Dr Nassar, University of Sheffield
- Dr Sansom, University of Glasgow
- Professor Secombes, University of Aberdeen
- Dr Sesardic, NIBSC
- Studentships
- Funded studentships
- Strategic awards
- NC3Rs / LASA Small Awards Scheme
- NC3Rs transfer to Je-S
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Dr Sloan, Cardiff University
An ex vivo mouse mandible culture model to study inflammatory bone disease Aims Using a novel method, slices of living periodontal tissue (tooth, gum, socket bone) from mice will be grown in the laboratory. Periodontal disease is a painful disease of the gums which can lead to loss of teeth. The aim is to initiate inflammation associated with periodontal disease in these tissue pieces and understand how the disease causes bone and tooth loss. The results will be used to identify new targets for treatment, or for developing methods for diagnosing the disease sooner. Currently, live mice are used in experiments to investigate the disease. Method All the tissues and cells of the mouse mandible will be cultured together so that we can investigate how they behave in an inflammatory disease condition and how this influences bone metabolism. The culture conditions will be manipulated to support the growth of a varied population of cells, which may be transplanted into, or exist naturally within, the system. Implications for the 3Rs The study will significantly reduce the amount of unnecessary animal experimentation currently used to study inflammatory cell activity in diseases such as periodontal disease. One animal will now contribute to ten individual experiments, rather than the current one animal per experiment scenario. It has strong potential to translate into clinical practice, contributing to the development of novel therapies. It will have widespread application in the reduction of animal experimentation in a number of other human diseases, such as rheumatoid arthritis and impaired bone fracture healing.
Publications - Singhrao SK, Sloan AJ, Smith EL & Archer CW (2010) Technical Advances in the Sectioning of Dental Tissue and of On-Section Cross-Linked Collagen Detection in Mineralised Teeth. Microscopy Research and Technique, Dec 1 [Epub ahead of print]
Read the abstract - Smith EL, Locke M, Waddington RJ & Sloan AJ (2010) An Ex-vivo Rodent Mandible Culture Model for Bone Repair. Tissue Engineering: Part C Methods, Apr 26 [Epub ahead of print]
Read the abstract
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