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  1. Derivation of conditionally immortalised mouse DRG cell lines

    Dr Mohammed Nassar, University of Sheffield (£387,392)

    Neuroscience research is particularly dependent on primary cultures of neuronal cells prepared from large numbers of rats and transgenic mice. This is because neurons do not naturally divide and so cannot be continuously propagated in vitro as cell c...

  2. Development of computational models of bone formation and resorption to predict changes in bone in preclinical intervention studies

    Dr Ilaria Bellantuono, University of Sheffield (£364,835)

    We want to develop computer programs to test new therapies for diseases of bone to reduce animal testing and accelerate research progress. Musculoskeletal disease including arthritis, osteoarthritis and osteoporosis are the most prevalent cause of wo...

  3. Refinement of behavioural analysis in a mouse model of motor neuron disease (MND): A feasibility study using running wheels

    Dr Andrew Grierson, University of Sheffield (£1,978)

  4. Refinement of therapeutic intervention in a mouse model of amyotrophic lateral sclerosis

    Dr Andrew Grierson, University of Sheffield (£164,760)

    Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease, is a neurological disease in which muscles waste away leading to loss of movement and basic functions like breathing, eventually resulting in death. There are approximately 5,00...

  5. The reduction in animal usage by multiple antigen immunisation schedules

    Dr Simon C Smith, University of Sheffield (£100,256)

    Antibodies are important biological molecules, widely used in clinical diagnosis, as therapeutic reagents and in academic research. Their development involves vaccinating animals (usually mice and rabbits) with the molecule of interest (antigen) in o...