A set of resources to support the adoption of the 3Rs in quality control and batch release testing of vaccines and biological therapeutics
Quarterly e-newsletter to keep the scientific community updated on news from the NC3Rs Toxicology and Regulatory Sciences programme.
Key results and recommendations from an EPAA/MEB/NC3Rs collaboration focused on chronic toxicity studies for monoclonal antibodies (mAbs).
Information and support for the adoption of alternative approaches and technologies.
A webinar to highlight available opportunities to minimising non-human primate use in drug development.
Opportunities to reduce the use of non-human primates in toxicology programmes.
A series of workshops as part of our project to implement the 3Rs in WHO guidelines.
Webinar showcasing ongoing and novel initiatives that replace, reduce and/or refine fish acute toxicity studies.
A virtual workshop to raise awareness of currently available New Approach Methodologies (NAMs) and overcome barriers to implementation.
Reducing and refining acute toxicity tests in the pharmaceutical and chemicals industries.
Providing an evidence base to refine and reduce the use of vertebrates in (regulatory) ecotoxicology studies
Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies
Supporting the uptake of new approach methodologies to reduce reliance on traditional animal toxicity tests
Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.
Projects providing guidance to reduce animal use or refine procedures within toxicology studies.
10 years of CRACK IT webinar: The Human In Vitro Gene Therapy Genotoxicity Testing service.
Paper clarifies that the forced swim test is not a regulatory requirement for the development of new antidepressants (NC3Rs & MHRA project).
10 years of CRACK IT webinar: A human stem cell-based in vitro system to assess cardiotoxicity in new drugs.
10 years of CRACK IT webinar: The NephroScreen human kidney-on-a-chip platform, which could replace in vivo nephrotoxicity studies in drug development
10 years of CRACK IT webinar: an in silico platform developed to model chronic Leishmania infection.
10 years of CRACK IT webinar: A C. elegans platform to assess the developmental and reproductive toxicity (DART) potential of chemicals.
Bibliography and relevant resources for those working in the field of toxicology and regulatory sciences.
A webinar presented as part of the SETAC SciCon 2020.