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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

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Reducing and refining acute toxicity tests in the pharmaceutical and chemicals industries.

A white mouse on a technician's gloved hands

Providing an evidence base to refine and reduce the use of vertebrates in (regulatory) ecotoxicology studies

A group of young rainbow trout

Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies

A lister hooded rat (black head white body) seen in a standard rat housing cage. The rat is standing on a plastic box and is looking out of the open cage lid.

Guiding strategy and encouraging the adoption of microsampling techniques within any research or safety study.

A brown and white rat in the gloved hands of an animal technician.

Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.

A beagle at an indoor play area

Quarterly e-newsletter to keep the scientific community updated on news from the NC3Rs Toxicology and Regulatory Sciences programme.

A white icon of an envelope on a purple background.

Paper clarifies that the forced swim test is not a regulatory requirement for the development of new antidepressants (NC3Rs & MHRA project).

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Examples of study designs that may be used for microsampling from either main study animals or from satellite groups of animals.

A lister hooded rat (black head white body) being held by a technician. The technician wears a green gown and purple gloves.