Reducing and refining acute toxicity tests in the pharmaceutical and chemicals industries.
Providing an evidence base to refine and reduce the use of vertebrates in (regulatory) ecotoxicology studies
Using exposure science to refine and reduce animal use, and support the uptake of new approach methodologies
Guiding strategy and encouraging the adoption of microsampling techniques within any research or safety study.
Supporting the uptake of new approach methodologies to reduce reliance on traditional animal toxicity tests
Guidance on reducing or refining animal use for studies with cardiovascular, central nervous system and respiratory functional measurements.
Projects providing guidance to reduce animal use or refine procedures within toxicology studies.
10 years of CRACK IT webinar: The Human In Vitro Gene Therapy Genotoxicity Testing service.
Quarterly e-newsletter to keep the scientific community updated on news from the NC3Rs Toxicology and Regulatory Sciences programme.
Paper clarifies that the forced swim test is not a regulatory requirement for the development of new antidepressants (NC3Rs & MHRA project).
10 years of CRACK IT webinar: A human stem cell-based in vitro system to assess cardiotoxicity in new drugs.
10 years of CRACK IT webinar: The NephroScreen human kidney-on-a-chip platform, which could replace in vivo nephrotoxicity studies in drug development
10 years of CRACK IT webinar: an in silico platform developed to model chronic Leishmania infection.
10 years of CRACK IT webinar: A C. elegans platform to assess the developmental and reproductive toxicity (DART) potential of chemicals.
Key papers and resources on the topic of microsampling.
Bibliography and relevant resources for those working in the field of toxicology and regulatory sciences.
A webinar presented as part of the SETAC SciCon 2020.
Examples of study designs that may be used for microsampling from either main study animals or from satellite groups of animals.