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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

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16 results

Guidance on best practices in confirming, archiving and maintaining strains, as well as re-establishing colonies after a pause.

A litter of black mice with an adult mouse, nesting in the corner of their home cage

A high level introduction to best practice in mouse colony management, including confirming, archiving and maintaining mouse strains.

White icons of a magnifying glass focused on a mouse, on a blue background

Archiving can provide a back-up to production colonies, minimise genetic drift, reduce the need for tick-over colonies and preserve valuable models.

A white sperm and egg icon on a blue background

F0-ols Rush In: Improving reproducibility and avoiding genetic mosaicism using CRISPR/Cas9 technology.

A white icon of the DNA double helix on a purple background.