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Webinar and video

Increasing confidence in NAMs for regulatory decision-making

In collaboration with the British Toxicology Society and the Health and Safety Executive’s Chemicals Regulation Division, the NC3Rs hosted a two-day virtual workshop in February 2022. 

The workshop aimed to raise awareness of currently available NAMs and explore how regulatory application and acceptance of these tools can be accelerated by overcoming the most significant barriers to their implementation. 

The workshop was split into five sessions:

  1. A vision for NAMs in safety testing
  2. OECD test method developments – current status of NAMs and lessons learnt
  3. Recent research developments in NAMs – Part I
  4. Recent research developments in NAMs – Part II
  5. NAMs and regulatory needs

Session recordings

S1: A vision for regulatory application of NAMs – personal reflections (Professor Alan Boobis, Imperial College London)

S2: Overview of recently adopted NAM OECD guidelines and future workplan (Dr Anne Gourmelon, OECD)

S2: Validation and standardisation of latest NAMs (Dr Nicole Kleinstreuer, NICEATM)

S3: Increasing confidence in chemical grouping using omics-derived molecular data (Professor Mark Viant, Michabo Health Science Ltd)

S3: Integrating in vitro bioactivity data, computational modelling and exposure science in animal-free cosmetic safety assessments (Dr Maria Baltazar, Unilever)

S3: Using (Q)SAR models as part of a weight of evidence, to reduce reliance on animal testing and support regulatory assessments (Dr Adrian Fowkes, Lhasa Ltd)

S4: Microphysiological systems – what is possible and what are the limitations? (Dr Jason Ekert, GSK)

S4: Importance of AOPs in NGRA – the case study of cardiotoxicity (Dr Luigi Margiotta-Casaluci, Kings College London)

S4: Novel in vivo mechanistic toxicology approaches to inform regulatory testing (Dr Francisco Inesta-Vaquera, University of Dundee)

S5: Barriers to and opportunities for the increased use of NAMs in the regulation of agrochemicals and biocides (Dr Susy Brescia, HSE CRD)

S5: Non-animal methods and new approach methodologies in UK REACH registration (Dr Helen McGarry, HSE CRD)

S5: The use of NAMs in regulatory assessments of cosmetics safety (Professor Qasim Chaudhry, University of Chester)

[The recording is not available]

S5: Current and future role of NAMs in regulatory assessments of food (Dr David Gott, FSA)

S5: Acceptance of NAMs in the regulation of pharmaceuticals – what are the challenges and how they can be overcome (Dr David Jones, Independent)