The American College of Toxicology's (ACT) Annual Meeting aims to update attendees on emerging trends in the discipline of toxicology. This year’s Annual Meeting will include a diverse scientific program, a welcome reception, a traditional poster reception session, social events in the exhibit hall to enhance broad interactions among attendees, students, and exhibitors, and more.
Dr Fiona Sewell will be speaking on Tuesday 8 November in Symposium 13: “The Inclusion of Recovery Groups in Repeat-Dose Studies: To Be or Not to Be?” Details on this symposium are below.
The pivotal and usually most important gatekeeping studies for drugs (and other new molecules with human systemic exposure) entering and subsequently advancing in clinical development are repeat dose GLP systemic (“general”) toxicology studies performed in one or two species and ranging from 14 days to 9 months of repeat test material administration. While there have been improvements in design details over the past 60 years, incorporation of new technologies and lessons learned have been limited and slow.
This symposium will review design changes to-date, and then specific proposals for improvement (“Use of Recovery Groups–Or Not,” “Changes in Blood Sampling Methods to Reduce Animal Usage in Rodent Studies,” “Multihousing of Animals to Provide Social Enrichment,” “Incorporation of New Biomarkers in Clinical Pathology,” and “Formulation, Route and Regimen for Nonclinical Studies for Improved Success in the Clinic”) presented by individual experts. An open discussion of potential improvements in studies will follow.
Practicing toxicologists and all those responsible for the planning, design, execution, and analysis of nonclinical safety evaluation programs for drugs and other regulated products, or for ensuring the safety of such products will benefit from this session.
Information on registration and travel can be found on the ACT website.