Pathways-based approaches across the biosciences: Towards application in practice

  • NC3Rs
Thursday 28 April 2016 09:00
Central London, UK

The NC3Rs is hosting a one-day workshop in Central London on 28 April 2016. This will bring together multi-disciplinary academic and industry researchers to share their knowledge and experiences in applying pathways-based approaches in practice. Widespread application of such approaches promises to improve safety assessment processes and reduce reliance on animal models.

The workshop will be attended by expert scientists from academia, government and regulatory agencies and the chemicals, consumer products, and pharmaceutical industries.

The key objectives of the workshop are to:

  • keep the UK science base abreast of developments in the field of pathways-based approaches, including adverse outcome pathways (AOPs);
  • expand the multidisciplinary community needed to accelerate the development and application of pathways-based approaches;
  • encourage transition towards application of the knowledge within established AOPs in product development and/or regulatory safety assessment.


The workshop will be chaired by Professor Ian Kimber OBE, Professor of Toxicology at the University of Manchester and will cover 1) Case studies: practical applications of pathways-based approaches; 2) AOPs: perspectives for future development and application; 3) Next steps to enable wider application of pathways-based approaches; and 4) An interactive roundtable discussion entitled ‘The big conundrum – what constitutes validation?’.

Confirmed speakers:

  • Dr Elisabet Berggren, European Commission Joint Research Centre, Italy
  • Professor Alan Boobis OBE, Imperial College London, UK
  • Dr Kevin Crofton, National Center for Computational Toxicology, EPA, USA
  • Dr Sylvia Escher, Fraunhofer Institute for Toxicology and Experimental Medicine, Germany
  • Dr John Paul Gosling, University of Leeds, UK
  • Dr Hennicke Kamp, BASF, Germany
  • Dr Dries Knapen, Universiteit Antwerpen, Belgium
  • Dr Magdalini Sachana, OECD, France
  • Dr James Sidaway, Phenotox, UK
  • Dr Chantal Smulders, Shell, Netherlands
  • Dr Carl Westmoreland, Unilever, UK
  • Dr Colin Wilde, AvantiCell, UK
  • Dr Marjolein Wildwater, Universiteit Utrecht, Netherlands
  • Dr James Wheeler, Dow AgroSciences, UK
  • Dr Maurice Whelan, European Commission Joint Research Centre, Italy

The draft agenda can be viewed here.


Delegates are encouraged to submit poster abstracts on a topic relevant to the theme of the meeting and highlighting the potential 3Rs benefits. To present a poster, please complete the abstract submission form and submit by 11 April 2016. We will let you know if you have been successful by 15 April 2016.


Attendance is free, but registration is essential.  The closing date for registration is 13 April 2016.

You will need an NC3Rs website account to register. Please use your institutional email address when registering.

Event status

Registration now closed