Experimental design and reporting

There are issues with the reproducibility of animal studies and whilst there are many potential explanations, experimental design and the reporting of studies have been highlighted as major contributing factors. If a study is not designed to yield robust results and publications are not reported with enough detail, the animals and research resources used in that study are wasted. Appropriate experimental design and statistical analysis techniques are key means of minimising the use of animals in research.

We have a number of resources to aid researchers to improve the design and reporting of research using animals.

Video presentation describing our resources and the importance of good experimental design.
An online tool to guide researchers through designing experiments involving the use of animals.
Download our reporting guidelines and find a range of additional resources to support their use and dissemination.
Visit our open access portal, hosted by F1000 Research, providing a place for NC3Rs-funded researchers to promote the 3Rs impacts of their work.
Key elements of a well designed experiment.
Tips to avoid common pitfalls when describing your experimental design and methodology with input from our Panel members.
A survey looking at the quality of research using animals, revealing problems in the design, analysis and reporting of animal studies.
Brief guidance on the importance of carrying out a pilot study.
NC3Rs project to explore and understand the current thinking around the choice of the age of rodents being used by researchers.
An online resource to help you perform systematic review and meta-analysis.
Dr Simon Bate, from Statistical Sciences, GSK, covers a few nagging questions about statistics and the 3Rs that he regularly encounters.
Videos from our May 2018 workshop on experimental design for panel members of the NC3Rs, BBSRC, CRUK, MRC and Wellcome Trust.
A webinar aimed at in vivo researchers or students with limited or no experience of systematic reviews.