NC3Rs e-newsletter - December 2017

 

Applying the 3Rs in non-human primate research: barriers, solutions and opportunities

 

Two recently published papers co-authored by NC3Rs staff members have explored the application of the 3Rs to non-human primate use. The first identifies barriers and solutions to applying the 3Rs, while the second explores opportunities to apply the 3Rs in drug discovery and development.

 

 
 

 
 

Using microsampling to further refine a mouse model of thrombosis

 

With further funding from the NC3Rs, Dr Mike Emerson from Imperial College London has made his refined mouse model of thrombosis, which avoids the use of paralysis and death as an endpoint, more accessible to labs that do not have the specialist expertise and facilities to use radioisotopes. Based on measuring platelets from microsamples of blood, the new method has been correlated with data obtained from real-time monitoring using radiolabelled platelets in mice and validated with the standard anti-thrombotic drug, aspirin.

 

 
 

 
 

Listen to the latest episode of "3 Minute 3Rs"

 

This month’s edition of “3 Minute 3Rs”, the podcast co-produced by LabAnimal and the NC3Rs, covers a new, less invasive “transparent ribcage” for imaging lung tumours in mice, the development of tissue chips for pharmaceutical research and the use of biomimetic robotic zebrafish in behaviour studies.

 

 
 

 
 

2017, the Year of Laboratory Rodent Welfare

 

Take a look back at our Year of Laboratory Rodent Welfare with our timeline of activities undertaken or funded by us throughout 2017 – from improving rat housing and refining mouse handling techniques to developing new home cage monitoring systems and studying mouse aggression.

 

 
 

 
 

Tickling rats: a social enrichment to improve rodent welfare

 

It has been almost 20 years since rat tickling was first demonstrated by the late Jan Panskepp, so we are taking a look at how this technique can improve rat welfare. Designed to mimic the play activity of juvenile rats, tickling has been shown to increase approach behaviour, decrease anxiety measures and improve handling. Megan LaFollette, Dr Brianna Gaskill and colleagues at Purdue University have developed excellent resources to help you introduce the technique in your lab.

 

 

 

Submit your outline to our 2018 project grant scheme

 

Our project grant scheme supports the development of new 3Rs approaches and technologies. Applications from any area of medical, biological or veterinary research are within remit; applications incorporating systematic reviews for 3Rs purposes are particularly welcomed due to our 2018 highlight notice. The deadline for submitting outlines via Je-S is 4pm, 10 January 2018.

 

 

 

CRACK IT 2018: Call for Challenges

 

We are now inviting submissions from Sponsors for new CRACK IT Challenges for the 2018 competition. The deadline for new Challenge submissions is 1 March 2018.

 

 

 
 

New Solution: BrainBits® – providing primary rat and mouse tissues and cells

 

Do you require a reliable source of primary rat and mouse cells and tissue for research?

BrainBits® provides microsurgically dissected tissues from rats and mice to researchers around the world, reducing the number of animals needed by taking multiple tissues from each animal. They are seeking collaborators to explore novel applications and develop new and existing technologies.

 

 

NC3Rs Cardiovascular Showcase

 

23 March 2018 (Central London)

Our one day Cardiovascular Showcase event will highlight the wide range of NC3Rs projects within cardiovascular science and bring together a diverse group of scientists working to advance the application of the 3Rs in cardiovascular research and safety assessment. It will feature presentations, posters and workshops, as well as three breakout sessions.

Attendance is free, but registration is essential (closing date: 8 February 2018).

 

 

 

Championing the 3Rs in India

 

NC3Rs staff members reflect on their involvement in the recent 8th International Conference of the Laboratory Animal Scientists’ Association (LASA) India in our latest blog. This new collaboration with Indian scientists and veterinarians is part of a wider strategy of the NC3Rs to engage and support scientific communities in BRIC countries.

 

 
 

 
 

Re-use of needles: is this an indicator of a culture of care?

 

The re-use of hypodermic needles is common in research facilities, but could this practice compromise the welfare of the animals as well as the quality of the science? Our latest guest blog post, from Dr Lucy Whitfield at the Royal Veterinary College and Dr Sally Robinson at AstraZeneca, explores this topic.