NC3Rs e-newsletter - January 2020

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January 2020


Professor Kevin Shakesheff appointed as NC3Rs Board Chair

We are pleased to announce that Professor Kevin Shakesheff of the University of Nottingham has been appointed as the new Chair of the NC3Rs Board. As NC3Rs Board Chair, Kevin will help to shape the NC3Rs strategy and promote the UK’s position at the forefront of 3Rs research and development.

 

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Professor Kevin Shakesheff


Apply now for the 2019 International 3Rs Prize

Have you published a paper describing outstanding and original work that has or could have major 3Rs impacts? If so, you should apply for our 2019 International 3Rs Prize, sponsored by GSK. This prestigious annual award, worth a total of £30k, recognises a paper published in the last three years with demonstrable 3Rs impacts.

 

The deadline to apply is 4pm (GMT) on Friday 6 March.
 

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2018 International 3Rs Prize winner Professor Rickie Patani


Minimising aggression in group-housed male mice

How big a problem is aggression in group-housed male mice, and what can be done to reduce its prevalence? To answer these questions, we crowdsourced data from technicians around the world, the first study of its kind to be applied to an animal welfare problem. The results of the study, including recommendations for reducing and preventing aggression in group-housed male mice, have now been published in Scientific Reports.

 

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Minimising aggression in group-housed male mice


Subscribe to our Tech3Rs newsletter – next issue coming soon

Our Tech3Rs newsletter highlights the latest resources, research and events for animal technicians. The next issue will be going live in February, available to read online and download via our website. If you are based in a UK facility, don’t forget to sign up for free hard copies to be mailed out to you every quarter.

 

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Tech3Rs November 2019 issue


Repeated immobilisation and subcutaneous injection do not reverse the positive effects of tunnel handling mice

New NC3Rs-funded research published in Scientific Reports shows that mice who are tunnel handled continue to experience positive welfare benefits even when undergoing certain procedures. In contrast, tail-handled mice display as much aversion and anxiety when they are only picked up by the tail as when they are also immobilised and injected. This work adds to the substantial evidence base supporting refined handling methods.

 

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Mouse handling with a tunnel


Visit our new public engagement pages

We have developed a new public engagement area on our website, featuring information about the 3Rs and their importance for a general audience. The hub brings together resources and ways to get involved, including our new citizen science project.

 

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Visit our new public engagement pages

3 Minute 3Rs podcast

Could your organisation sponsor a 2020 CRACK IT Challenge?

We are seeking organisations to sponsor CRACK IT Challenges for the 2020 competition. As a Sponsor, you will identify a scientific Challenge that could deliver commercial and 3Rs benefits if solved, and also provide funding or in-kind contributions to support its solution. In return, you will receive early access to the innovative 3Rs technologies that emerge from your Challenge.

 

The deadline to submit your Challenge is Monday 2 March.

 

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Sponsor a CRACK IT Challenge in 2020


£1.75 million awarded to deliver the 2018 CRACK IT Challenges

Two teams have been awarded funding to deliver Phase 2 of the 2018 CRACK IT Challenges ImmuLiver and RaTS. ImmuLiver aims to replace the use of macaques in the safety testing of the yellow fever vaccine by developing an immunocompetent in vitro model of the liver, while RaTS aims to refine rodent models of rheumatoid arthritis using non-invasive imaging.

 

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£1.75 million awarded to deliver the 2018 CRACK IT Challenges

16 new NC3Rs-funded PhD Studentships awarded

We are pleased to announce that we have awarded 16 new PhD Studentships, totalling £1.44 million. These awards will embed the 3Rs in the training of early career researchers across a range of disciplines. Interested students should contact prospective supervisors directly – visit our Studentship vacancies page for contact details.

 

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NC3Rs-funded PhD Studentships


Meet our newest Training Fellows

We have awarded four new NC3Rs Training Fellowships, totalling £512k, to support the development of talented 3Rs-minded postdoctoral researchers. The Training Fellows will address key scientific questions with 3Rs relevance, encompassing computational models of extracellular matrices, a microfluidic in vitro model of the retina, the effects of X-rays in small laboratory animals and a zebrafish model of congenital myopathy.
 

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Meet our newest Training Fellows


researchfish® submission period opens soon

This year’s researchfish® submission period will run from 3 February until 4pm on 12 March. We will use the submitted information to showcase your 3Rs research and identify how we can use our expertise and networks to help maximise your impacts, so please take this opportunity to share the outcomes of your 3Rs research. Take a look at this analysis of last year’s researchfish® submissions (PDF).

 

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researchfish®

 

AST 2020 session: “New Technologies Which Advance Refinement and Science”

Wednesday 25 March, 2-4pm (Edinburgh, UK)

 

AST 2020, a joint conference between LASA, LAVA and IAT, will take place from Tuesday 24 to Thursday 26 March. We are sponsoring a session on technologies that can facilitate research and improve welfare. Come along to learn about new tools that can analyse mouse ultrasonic vocalisations, train non-human primates in their home cage, and monitor individual behaviour or food intake in group-housed mice.

 

To register for the AST 2020 conference, visit www.ast2020.org.

 

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AST2020

Changing mouse handling practice at a university establishment: an NTCO's perspective

Lesley Gilmour is the University of Glasgow’s Named Training and Competency Officer (NTCO), responsible for ensuring that all those working with animals are appropriately, trained, supervised and competent. In this blog post, she shares her experience of implementing refined mouse handling across the institution, including some top tips.

 

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Changing mouse handling practice


Making refinements a reality – why we can be proud

Animal care staff at the University of Dundee's Medical School Resources Unit have put a number of refinements into practice over the past 18 months, including improving environmental enrichment and refining their breeding colonies. In this guest blog post, based on a platform presentation at IAT Congress 2019, animal technician Joanne King shares some of these changes and how they've made a difference.

 

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Making refinements a reality


Highlights from the 2019 NC3Rs/IAT Animal Technicians’ Symposium

In this blog post we look back at our 2019 Animal Technicians’ Symposium, a joint event with the IAT. As well as sharing the winners of the technicians' poster prize, we summarise key points from three of the day's talks, delivered by experts in laboratory animal welfare and refinement.

 

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The 2019 NC3Rs/IAT Animal Technicians’ Symposium

LASA Animal Science (Transgenics) Section Workshop – cryopreservation and IVF technology

Monday 22–Tuesday 23 June (venue TBC)

 

The first day of this two-day workshop will be seminar-based, with lectures on embryology of the mouse, metabolism of the preimplantation mouse embryo (and media) and an overview of cryobiology. The second day will form part of a technical forum with discussion focusing on topics such as innovations and tips for cryopreservation, assisted reproductive technology, refinements and ethical considerations for those working in this field.

 

For further information and to register for one or both days, contact info@lasa.co.uk.

 

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LASA