The ARRIVE guidelines have been revised to further support researchers in improving the reliability and reproducibility of their work through better reporting. Items within the guidelines, now published in PLOS Biology, have been organised into two sets to help researchers include the most important information within their manuscript. ARRIVE 2.0 is accompanied by an Explanation and Elaboration document, as well as a new website, www.arriveguidelines.org, which features information and resources for researchers, journals, funders and other stakeholders.
A new project to reduce animal use in the batch release and quality control testing of biologicals
We have been funded by the Bill & Melinda Gates Foundation to review animal use in World Health Organization guidelines for the quality control and batch release testing of biologics and vaccines. The project aims to identify how non-animal approaches can accelerate access to vaccines globally.
Embedding the 3Rs in COVID-19 return to research plans
As in vivo researchers around the world return to work following the COVID-19 lockdown, keeping the 3Rs a priority remains crucial. We have produced new guidance on key considerations and resources for researchers returning to working with laboratory animals.
We have created a new hub providing advice on the 3Rs aspects of a UK project licence application, focusing on each 'R' in turn. This information is also relevant for more experienced project licence holders and members of the Animal Welfare and Ethical Review Body (AWERB).
Rodent high-yield behavioural experiments: last chance to fill in our survey
The deadline for our survey on best practice in rodent high-yield behavioural experiments has been extended to Friday 24 July. If you work in this area as a researcher, technician or veterinarian and have not yet filled it in, please take half an hour to participate.
We are currently running a survey targeted to end-users of organ-on-a-chip technology. The aim of the survey is to gather information on the current use and application of the technology, provide insight into the impacts on the 3Rs and to help inform the NC3Rs’ future strategy in this area. If you are currently using, considering using or have used organ-on-a-chip technology, please take 30 minutes to complete the survey before Friday 14 August.
This year’s Training Fellowship scheme is now open for applications. Our Fellowships support the development of promising early career researchers with less than three years’ post-doctoral experience, focusing on developing new skills and gaining a breadth of research experience.
We are running a webinar on Tuesday 21 July at 11am (BST) for anyone interested in applying for this year’s scheme to learn more and ask questions about eligibility, remit and making a competitive application.
Dr Esther Pearl (NC3Rs) and Dr Natasha Karp (AstraZeneca) will provide an introduction to best practice in experimental design for both in vitro and in vivo experiments. This 90 minute webinar, aimed at PhD students and postdoctoral researchers, will cover topics including reproducibility, randomisation, sample size and the ARRIVE guidelines 2.0.
A change in (cell) culture: exploring alternatives to fetal calf serum
Fetal calf serum (FCS) is widely used in research, but it presents both scientific and ethical limitations. Our latest guest blog post by Dr Jan van der Valk, Director of the 3Rs-Centre Utrecht Life Sciences, explores why FCS-free media are important and how the FCS-Free Database can support scientists.
Recent articles in the scientific press have questioned whether the 3Rs should be replaced by a broader ethical framework for animal research. In this blog post, Dr Mark Prescott, NC3Rs Director of Policy and Outreach, explains why this could jeopardise the progress already being made.