NC3Rs e-newsletter - March 2015

 

NC3Rs 2014 annual report published

Our Annual Report 2014 features highlights from our tenth anniversary year. This year we have produced the report in a new interactive online format, bringing our achievements from over the past year to life and allowing you to delve deeper into our impacts and case studies.

 
 

 
 

2014 NC3Rs 3Rs Prize winners announced

A new approach which models physiological heterogeneity has been recognised for its potential to reduce the number of animals used in research, particularly in the safety assessment of new drugs. This year's winner, Mr Oliver Britton, a PhD student from the University of Oxford, has won an £18k research grant to further the work and a £2k personal award.

Three additional papers were recognised as highly commended.

 
 

 
 

Join the Non-Animal Technologies Special Interest Group (NAT SIG)

Sign up to our special interest group for news, events, funding opportunities and discussion. The community forum and news repository, developed by the NC3Rs in partnership with Innovate UK, connects the research and business communities to commercialise novel technologies to reduce reliance on animal models.

 
 

Novel technologies to overcome challenges

Nine research and development consortia have been awarded up to £100k each, to solve three Challenges faced by the pharmaceutical and chemical industries.

 

 
 

 
 

Solutions: Partners sought
GentleSharp - a more humane system for small volume blood sampling in PK and toxicology research.
 

GentleSharp, Inc., is seeking partners to help validate their blood sampling technology in diverse animal species. The technology enables the same animal to be sampled at multiple time points, decreasing variability in the data and the total number of animals needed per study.

 

 

 

Delivering lasting 3Rs benefits in the safety assessment of chemicals

A new paper published in Toxicology, summarises discussions held at a recent NC3Rs workshop attended by more than 20 international experts in the field of chemical safety assessment. Written in collaboration with authors from the chemicals industry and academia, the paper reviews the current scientific, technical and regulatory landscapes, and identifies key opportunities to move away from the reliance on in vivo toxicity testing for the purposes of chemical safety assessment.

Human tissue models for a human disease: what are the barriers?

Human tissue-based approaches offer exciting opportunities for investigating human (patho)biology. However recent work from the NC3Rs Asthma Advisory Group has highlighted the difficulties scientists face in adopting these approaches. Published in Thorax, the paper describes the findings of a survey of the UK asthma research community to better understand the extent of human tissue use in asthma research and the barriers to wider uptake.

 
 

NC3Rs/Society of Biology 3Rs Symposium

10 June 2015 – LONDON
Register now for our one day symposium with the Society of Biology's Animal Sciences Group. Showcasing the latest scientific and technological advances in the 3Rs, speakers from across academia and industry will present on a range of topics, from thermal imaging to experimental design.

 
 

The one-year dog study in agrochemical testing: time for a global change

A recent publication in Critical Reviews in Toxicology, co-authored by a number of companies, has highlighted the redundancy of the one-year dog study in assessing human health risks for the registration of pesticides. The paper uses data from Japan, where the study is still routinely required. Claire Terry, Global Toxicologist from Dow Agrosciences, discusses the implications.

 

 
 

Publication bias workshop

In February we held a two day workshop on publication bias, encouraging delegates to share their thoughts online using the hashtag #publicationbias. We have used a service called Storify to aggregate the online conversation, now on the blog.