New CRACK IT Solution: Extrapolating in vitro to in vivo toxicity for predicting effects on growth in rats and mice

Researchers at the University of York are seeking partners with expertise in mammalian cell culture to develop novel mathematical approaches for in vitro to in vivo extrapolation. Such models developed as part of a suite of tests have the potential to reduce the use of animals in chronic toxicity studies.

The proposed approach uses toxicokinetic and toxicodynamic modelling and has successfully predicted toxic effects of chemicals on fish growth.

Now, the researchers want to apply the approach to predicting toxic effects in rats and mice. The model will be calibrated using data generated in in vitro toxicity tests. The Solution providers have extensive expertise in modelling, and access to existing in vivo toxicity data via a collaborator to test the approach for small mammals. They are looking for a partner who can carry out the in vitro toxicity tests with cultured mammalian cells.

For more information or to contact the Solution provider, visit the CRACK IT website.

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