NC3Rs e-newsletter - November 2017

 

Listen to our new monthly podcast, co-produced with LabAnimal

 

We have teamed up with LabAnimal, a Nature Research journal, to bring you “3 Minute 3Rs”, a new monthly podcast summarising the latest research and news in 3Rs science and technology. You can listen and subscribe to the podcast via SoundCloud or iTunes.

 

 
 

 
 

Cell-based model means a step forward for Creutzfeldt-Jakob disease research

 

Researchers from the University of Edinburgh have developed a new system that allows Creutzfeldt-Jakob disease to be studied in vitro using astrocytes derived from human induced pluripotent stem cells. The work, funded by an NC3Rs project grant, has the potential to replace some animal studies of human prion disease.

 

 
 

 
 

New cell line developed for testing botulinum toxin activity

 

A new cell-based assay developed with NC3Rs funding could replace the use of animals in pharmaceutical botulinum neurotoxin testing. Researchers at the University of Sheffield used an engineered neuroblastoma cell line to test botulinum neurotoxin serotype B, a method that was shown to be more sensitive than the current ‘gold standard’ in vivo assay.

 

 
 

 
 

Reducing variability in experimental stroke models

 

Researchers at the University of Leicester funded by an NC3Rs pilot study grant have developed a new approach for inducing ischaemic stroke in mice that minimises the variation in lesion volume between animals, allowing the number of animals per study to be reduced.

 

 
 

 
 

Watch our experimental design resource overview video

 

The Head of Experimental Design and Reporting at the NC3Rs, Dr Nathalie Percie du Sert, describes the Experimental Design Assistant, ARRIVE guidelines and Systematic Review Facility.

 

 
 

 
 

3Rs prize winner publishes more ground-breaking research

 

Mini-tumours have been grown from patients’ own tumour cells for the first time, potentially reducing the number of animals needed for liver cancer research, while providing a more biologically accurate model. The team led by Dr Meritxell Huch, past 3Rs Prize winner, has recently been awarded an NC3Rs project grant.

 

 

 

Fifteen new NC3Rs PhD studentships announced

 

We have awarded 15 PhD studentships totalling £1.35 million. Three of the awards are co-funded with the British Heart Foundation to support 3Rs training and development in cardiovascular research.

 

 
 

 
 

Up to £1,500 available for 3Rs public engagement

 

If you are an NC3Rs-funded researcher (past or present) who would like to engage the public in 3Rs research, you can apply for up to £1,500 from our public engagement awards. The funding is available as an open rolling call, with applications being reviewed quarterly by the NC3Rs Office.

 

 

 

New Solution: iSafeRabbit QSAR models for regulatory irritation and corrosion testing

 

KREATiS is seeking partners to help test and validate their new in silico models for screening skin and eye irritants. The iSafeRabbit QSAR models were developed to address the QSARs Mix CRACK IT Challenge, and offer better toxicity prediction than existing irritation models (in vivo and in vitro) when tested against known chemicals.

 

 

 

Data, data, data: Applying Maths to 3Rs problems - a case study

 

Manasi Nandi of King’s College London uses mathematical modelling to improve the analysis of cardiovascular data, which could bring both 3Rs and clinical benefits. Read her blog post, the last in our ‘Data, data, data’ series, to learn more about her work and how it developed from an NC3Rs workshop.