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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research
PhD Studentship

Combinatorial mathematical modelling & novel toxicological profiling of drug-induced hepatotoxicity


At a glance

Award date
October 2012 - September 2016
Grant amount
Principal investigator
Dr John Ward


Loughborough University


  • Reduction
  • Replacement
Read the abstract
View the grant profile on GtR

Application abstract

Adverse drug reactions are a serious concern for both public health but also during drug development. Drug-induced hepatotoxicity is a primary reason for the failure of new medicines. There is considerable research into mechanistic evaluations of why compounds fail in development. There is currently no systematic framework which is able to direct research into areas of data deficiency. This application seeks to combine innovative mathematical modelling with state-of-the-art technologies in toxicological research, in order to establish a theoretical/experimental protocol that produces the most informative data with reduced animal testing.


  1. Reddyhoff D et al. (2015). Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. Journal of Theoretical Biology 386:132-146. doi: 10.1016/j.jtbi.2015.08.021