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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

538 results

Defining drug delivery into and across the oral mucosa using a tissue engineering and mathematical modelling approach

Principal Investigator: Professor Craig Murdoch University of Sheffield

Project grant

Reducing and replacing the animal cost of functional genetics in African trypanosomiasis

Principal Investigator: Dr Catarina Gadelha University of Nottingham

Project grant

Preclinical Radiomics: A novel approach linking imaging with biological outcomes in mouse models

Principal Investigator: Dr Kathryn Brown Queen's University Belfast

Fellowship

Validation of an in vitro humanised 3D haematopoietic system to investigate haematological malignancies

Principal Investigator: Professor Helen Wheadon University of Glasgow

Project grant

Refinement of tickling protocols to improve positive animal welfare in laboratory rats

Principal Investigator: Professor Alistair Lawrence Scotland’s Rural College

Project grant

A white rat in a clear plastic cage with wooden shavings, being tickled by a gloved hand.

Establishing Drosophila melanogaster as part of the pre-clinical pipeline for anti-metastatic cancer drug discovery

Principal Investigator: Dr Kyra Campbell University of Sheffield

Project grant

Transfer of an in vitro model for the evaluation of anticoccidial compounds

Principal Investigator: Dr Virginia Marugan-Hernandez Royal Veterinary College

Skills and Knowledge Transfer grant

Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology

Principal Investigator: Dr Rachel Oldershaw University of Liverpool

PhD Studentship

Targeted protein degradation as a novel approach to study protein function in human platelets

Principal Investigator: Professor Ingeborg Hers University of Bristol

PhD Studentship

A novel in vitro reporter system for blood stem cell activity

Principal Investigator: Dr David Kent University of York

PhD Studentship

Refining the tagging of wild fish and sharks

Principal Investigator: Dr Matthew Witt University of Exeter

PhD Studentship

Dr Matthew Witt with two boats on grass in the background

Understanding how altered brain metabolism causes mitochondrial disease

Principal Investigator: Dr Joseph Bateman King's College London

PhD Studentship

Combining a fully synthetic hydrogel with human intestinal organoids to model pathological matrix remodelling in Inflammatory Bowel Disease

Principal Investigator: Dr Eileen Gentleman King's College London

PhD Studentship

3D bioprinted microtissues to develop patient-specific non-animal technologies (NAT) in cancer drug development

Principal Investigator: Dr Deepali Pal Northumbria University

PhD Studentship

Deepali Pal using a microscope. A colleague is beside her looking at a screen

Insects as models to study wound healing, infection and the wound microbiome

Principal Investigator: Dr Ronan McCarthy Brunel University

PhD Studentship

A 3Rs approach to investigate the feto-maternal interface: visualisation of pathogen and antibody in a 3D in vitro human placental model

Principal Investigator: Professor Aras Kadioglu University of Liverpool

PhD Studentship

Development and validation of 3D in vitro dormant myeloma cell models to reduce and replace animal studies

Principal Investigator: Dr Michelle Lawson University of Sheffield

PhD Studentship

Live monitoring of foreign-body response in animals by diffuse Raman spectroscopy

Principal Investigator: Professor Ioan Notingher University of Nottingham

Project grant

Development of a New Human Model of Lung Squamous Cell Carcinoma Progression

Principal Investigator: Dr Carlos Lopez-Garcia University of Manchester

Project grant

Establishing the novel ex-vivo focal demyelination model of Multiple Sclerosis in other laboratories to reduce and replace live animal use

Principal Investigator: Dr Ben Newland Cardiff University

Skills and Knowledge Transfer grant