Search our portfolio

Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

533 results

Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs

Principal Investigator: Dr Michael Chappell University of Warwick

Strategic grant

An orange Eppendorf rack partly full of PCR tubes.

Human pluripotent stem cell cardiomyocytes and hepatocytes with engineered genotypes for drug safety evaluation

Principal Investigator: Professor Chris Denning University of Nottingham

Project grant

Validating reward-related behaviour for welfare assessment, and improving welfare through increased predictability of events

Principal Investigator: Professor Hannah Buchanan-Smith University of Stirling

Project grant

State of the art in vitro models which accurately predict human liver toxicity

Contractor: Dr Dave Hay

CRACK IT Solution

Establishment of consensual husbandry protocols for laboratory Xenopus laevis using novel physiological and behavioural techniques

Principal Investigator: Dr Charlotte Hosie University of Chester

Project grant

A stock image of round glass dishes containing blue and green liquid arranged closely together.

Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes

Principal Investigator: Dr Gary Mirams University of Oxford

Strategic grant

A new sensor platform combining plastic antibodies with simple thermal detection

Contractor: Dr Marloes Peeters

CRACK IT Solution

Sensor platform combining plastic antibodies with simple thermal detection

Developing an in vitro approach to study transmission of respiratory viruses

Principal Investigator: Professor Wendy Barclay Imperial College London

Project grant

Individually customisable, non-invasive head immobilisation for primates with the option for voluntary engagement

Principal Investigator: Professor Christopher Petkov Newcastle University

Pilot study grant

Development and validation of an automated test of animal affect and welfare for laboratory rodents

Principal Investigator: Professor Michael Mendl University of Bristol

Project grant

Use of PrP transgenic Drosophila to measure mammalian prion infectivity

Principal Investigator: Dr Raymond Bujdoso University of Cambridge

Project grant

eGUT: a Tool for Predictive Computer Simulation of the Gut Microbiota and Host Interactions

Principal Investigator: Dr Jan-Ulrich Kreft University of Birmingham

Project grant

Improving the principles of the 3Rs through new integrative metabolomic and gene expression resources for signalling studies in burn injuries

Principal Investigator: Dr Istvan Nagy Imperial College London

PhD Studentship

a photo showing a glass slide being held by a scientist, near to a microscope

Refining the study of fatigue in mouse models of chronic liver disease

Principal Investigator: Dr Claire Richardson Newcastle University

Fellowship

Dr Claire Richardson sat next to a laboratory cage of mice preparing to handle an animal using a tunnel

CRANNME: The complete removal of animal use for neuromuscular effectors testing

Principal Investigator: Professor Mark Lewis Loughborough University

Pilot study grant

Non-invasive imaging to reduce and refine the use of animals and monitor their welfare during the course of experimentations in oncology

Principal Investigator: Dr Francois Lassailly Cancer Research UK

Pilot study grant

In vitro methods for replacement of current in vivo assays for development of drugs against heterogeneous cancer stem cell populations

Principal Investigator: Dr Adrian Biddle Queen Mary University of London

Fellowship

The role of bronchoconstriction in the development of airway remodelling and its effects upon lung function

Principal Investigator: Dr Amanda Tatler University of Nottingham

Fellowship

Investigation of behavioural and physiological responses to fin-clipping in zebrafish

Principal Investigator: Ms Gidona Goodman University of Edinburgh

Pilot study grant

Optimising liver equivalents to model liver fibrosis

Principal Investigator: Dr Fiona Oakley Newcastle University

Pilot study grant