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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

Activity type

Topic

Model

533 results

Genetic screens in intestinal/colon organoid (mini-gut) culture using the CRISPR-Cas9 system

Principal Investigator: Dr Abdolrahman Shams Nateri University of Nottingham

PhD Studentship

Dr Abdolrahman Shams Nateri with seven colleagues in white lab coats

Transfer of a non-human primate (NHP) in vitro functional assay for the early evaluation of TB vaccine candidates and the associated immune response

Principal Investigator: Dr Rachel Tanner University of Oxford

Skills and Knowledge Transfer grant

Dr Rachel Tanner sitting down beside a microscope

Interrogating the mouse visual system by automated analysis of voluntary behaviour

Principal Investigator: Dr Riccardo Storchi University of Manchester

Fellowship

The establishment of left-right asymmetry in mammalian development

Principal Investigator: Dr David Turner University of Liverpool

Fellowship

Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts

Principal Investigator: Dr Anna Grabowska University of Nottingham

PhD Studentship

Neuroinflammation and nociception in a dish

Contractor: Professor Adalberto Merighi

CRACK IT Solution

Neuroinflammation and nociception in a dish

Non-invasive in vivo tissue imaging with functional optical coherence tomography (OCT)

Contractor: University of Washington

CRACK IT Solution

Four 3D structual images of tissue of tissue imaging with functional optical coherence tomography

Training in hIPSC differentiation protocols to generate motor neuron-muscle cultures to replace rat models in study of mitochondria on axon physiology

Principal Investigator: Dr Mark Rigby King's College London

Fellowship

A 3D in vitro glioblastoma cell culture system for identification and evaluation of novel radiosensitisers reducing rodent xenograft studies

Principal Investigator: Professor Anthony Chalmers University of Glasgow

Project grant

Development of new experimental models to understand the genetic basis of allergic bronchopulmonary aspergillosis

Principal Investigator: Dr Sara Gago University of Manchester

Fellowship

Design, Fabrication and Testing of a Mouse Embryo Culture Chip

Contractor: Dr Virginia Pensabene, University of Leeds

CRACK IT Challenge

Integrated web platform for agro-chemical formulation toxicity classification and data sharing

Contractor: Professor Jonathan Timmis, SimOmics Ltd

CRACK IT Challenge

An industrial standard cancer drug development platform using human induced pluripotent stem cell technology

Principal Investigator: Dr Deepali Pal Newcastle University

Fellowship

Standardisation of preclinical PET/CT protocols across multiple research centres

Principal Investigator: Dr Adriana Tavares University of Edinburgh

PhD Studentship

Automated predictive welfare assessment in groups of fish

Principal Investigator: Professor Oliver Burman University of Lincoln

Project grant

Towards in vitro oncology trials: drug testing in cultured patient derived tumour organoid cultures

Principal Investigator: Professor Andrew Tutt King's College London

Project grant

Inter-neuronal variability in human nociceptor electrophysiology: experimentally-driven computational study of response to drugs and channelopathies

Principal Investigator: Dr Oliver Britton University of Oxford

Project grant

Unravelling the mechanism of transcellular chaperone signalling in C. elegans

Principal Investigator: Dr Patricija van Oosten-Hawle University of Leeds

Project grant

Using chicken eggs to advance the 3Rs in cancer drug discovery

Contractor: Dr Jean Viallet

CRACK IT Solution

Injecting a chicken egg under a spotlight

TruLarv Galleria mellonella - a model host for infection studies, toxicity testing and drug development (Partnering with Demuris)

Contractor: Dr Olivia Champion

CRACK IT Solution

Galleria mellonella larvaes in a green tub