Refinement of soft tissue targeting and alignment protocols is small animal radiotherapy using an injectable fiducial marker Principal Investigator: Dr Karl Butterworth Queen's University Belfast PhD Studentship
Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning Principal Investigator: Dr Andreas Bender University of Cambridge PhD Studentship
Multiphoton imaging in human liver tissues: validation of a new tool for drug discovery Principal Investigator: Dr Scott Davies University of Birmingham Fellowship
Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research Principal Investigator: Dr Alan Harper Keele University PhD Studentship
The Refining Dog Care online learning platform - a modular learning resource for those working with dogs in research Principal Investigator: Dr Laura Scullion Hall University of Stirling Skills and Knowledge Transfer grant
Replacing animal models in fungal pathogen research: An in vitro Titan virulence assay for the human fungal pathogen Cryptococcus neoformans Principal Investigator: Dr Elizabeth Ballou University of Birmingham PhD Studentship
Development of E-Sense: a flexible in vitro platform to determine cardiovascular risk Principal Investigator: Dr Stephen White Manchester Metropolitan University PhD Studentship
The role of water chemistry in zebrafish welfare and reproducibility of research studies Principal Investigator: Professor Roderic Wilson University of Exeter Project grant
Using wireless recording technologies to investigate cortical coherence in a mouse model of dementia Principal Investigator: Dr Jonathan Brown University of Exeter Skills and Knowledge Transfer grant
A live model to study mucociliary clearance in health and disease Principal Investigator: Professor David Thornton University of Manchester Project grant
A highly sensitive replacement assay for botulinum neurotoxin type B Principal Investigator: Dr Andrew Peden University of Sheffield Project grant
DARTpaths: Mapping developmental and reproductive toxicity (DART) genes and pathways for cross-species comparison of toxic compound effects Contractor: Professor Raymond Pieters, University of Applied Sciences Utrecht (UASU) CRACK IT Challenge
Development and evaluation of the Animal Welfare Assessment Grid (AWAG) Contractor: Mr Mike Dennis, Public Health England CRACK IT Solution
Novel approach to model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells Principal Investigator: Dr Carola Morell University of Cambridge Fellowship
Generating in vitro human optic vesicles to dissect the genetic modifiers affecting ocular maldevelopment Principal Investigator: Dr Mariya Moosajee University College London PhD Studentship
Development of the chick embryo as a replacement for rodent models of tumour metastasis Principal Investigator: Dr Anne Herrmann University of Liverpool Fellowship
Galleria mellonella - a novel infection model for Mycobacterium tuberculosis aimed at reducing the number of animals in experimentation Principal Investigator: Professor Paul Langford Imperial College London PhD Studentship
Identifying more clinically effective analgesic regimens and potential strain differences in pain perception in mice using a novel Operant Pain Assay Principal Investigator: Dr Matt Leach Newcastle University Project grant
Identifying regulators of tissue regeneration by in vivo imaging in the zebrafish Principal Investigator: Dr Robert Knight King's College London PhD Studentship
RespiraTox: In silico model for predicting human respiratory irritation Contractor: Dr Sylvia Escher, Fraunhofer ITEM CRACK IT Challenge