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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research
Pioneering better science

Our portfolio

Details of all of the NC3Rs work – including research and innovation funding, early career awards and projects led by our staff.
View all NC3Rs projects

Types of projects

A list of all grants awarded for the development and uptake of new 3Rs approaches and the training of early career scientists.


A list of all awards made for the development of 3Rs products and services through CRACK IT Challenges, our open innovation funding competition.


A list of all projects led by NC3Rs staff to embed the 3Rs in policy, practice and regulations nationally and internationally.

3Rs publications

The NC3Rs gateway

Maximising the 3Rs impact of NC3Rs-funded research by providing a platform for our grant holders to promote the 3Rs impact of their work, and publish rapidly, in an open and transparent manner.

Visit the gateway
A row of plastic fish tanks holding zebrafish at a laboratory. The tanks are tall and narrow, and sit next to each other in numbered racks. The whole aquarium has a blue hue to it. You can see many zebrafish in each tank, socially housed.

Latest news and publications from our grant holders and staff

Prof Helinor Johnston describes two potential methods to screen for a pro-inflammatory response in transgenic larval zebrafish replacing rodent models.

A new paper coauthored by Dr Emma Biglin shares work from her NC3Rs-funded PhD on a 3D-printed mouse phantom.

We are recruiting for up to two members, one of these new appointments will also be appointed as Chair of the CRACK IT Advisory Panel.

Find opportunities to collaborate on 3Rs projects via our innovation brokerage platform.

3Rs Publications

Publications from NC3Rs funding

Visit EuropePMC to view all publications attributing NC3Rs funding.

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Laboratory equipment