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Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel

Institution: 

  • Brunel University
  • Strategic grant

Improving biological integration of osseous and dermal tissues in macaque cranial implants

Institution: 

  • Newcastle University
  • Strategic grant

DictyMyc: Using Dictyostelium to study the genetic basis of Mycobacterium bovis intracellular infection

Institution: 

  • University of Surrey
  • Strategic grant

Developing and validating an in vitro mycobacterial challenge model to facilitate TB vaccine research and minimise in vivo challenge

Institution: 

  • University of Oxford
  • Strategic grant

A bovine alveolus model to replace cattle in the study of host-pathogen interactions in bovine tuberculosis

Institution: 

  • University of Surrey
  • Strategic grant

A non-mammalian model to study innate immune modulation of airways remodelling in asthma

Institution: 

  • University of Sheffield
  • Strategic grant

Developing a non-animal model system to investigate bitter tastants as new treatments for asthma

Principal Investigator: 

  • Professor Robin Williams

Institution: 

  • Royal Holloway University of London
  • Strategic grant

Developing a model for the study of respiratory inflammation in the zebrafish

Principal Investigator: 

  • Professor Margaret Dallman

Institution: 

  • Imperial College London
  • Strategic grant

Use of Drosophila models to explore the function of asthma susceptibility genes

Principal Investigator: 

  • Professor Donna Davies

Institution: 

  • University of Southampton
  • Strategic grant

Ultrasound mediated bioluminescence tomography for high sensitivity, high spatial resolution 3D imaging

Principal Investigator: 

  • Professor Stephen Morgan

Institution: 

  • University of Nottingham
  • Strategic grant

Targeted, radiolabelled near-infrared quantum dots for high sensitivity and resolution, dual modality imaging of human tumours in mice

Principal Investigator: 

  • Dr Anna Grabowska

Institution: 

  • University of Nottingham
  • Strategic grant

Non-invasive real-time bioluminescence imaging in living mice to interrogate transcription factor activity and fate of engrafted stem cells

Institution: 

  • Manchester Metropolitan University
  • Strategic grant

Labelled IMS TAG Proteins for Quantitative Mass Spectrometry Imaging

Principal Investigator: 

  • Professor Malcolm Clench

Institution: 

  • Sheffield Hallam University
  • Strategic grant

Implanted optical imaging laboratories for deep-tissue in vivo imaging

Principal Investigator: 

  • Professor Andrew Harvey

Institution: 

  • University of Glasgow
  • Strategic grant

Assessing the humaneness of gas euthanasia techniques for laboratory rodents

Principal Investigator: 

  • Dr Huw Golledge

Institution: 

  • Newcastle University
  • Strategic grant

A tissue engineered construct to monitor mucosal immunity in asthma

Principal Investigator: 

  • Professor Donna Davies

Institution: 

  • University of Southampton
  • Strategic grant

Developing a platform of in vitro models of asthmatic and healthy lung: an alternative to the use of animals in asthma research

Principal Investigator: 

  • Dr Felicity Rose

Institution: 

  • University of Nottingham
  • Strategic grant

Imprecision and importance: Probabilistic graphical models in toxicology

Principal Investigator: 

  • Dr Jonathan Pitchford

Institution: 

  • University of York
  • Strategic grant

Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs

Principal Investigator: 

  • Dr Michael Chappell

Institution: 

  • University of Warwick
  • Strategic grant

Uncertainty and confidence in applying mathematical models and in vitro data in toxicological safety assessments

Principal Investigator: 

  • Dr John Gosling

Institution: 

  • University of Leeds
  • Strategic grant

Prediction of human cardiotoxic QT prolongation using in vitro multiple ion channel data and mathematical models of cardiac myocytes

Principal Investigator: 

  • Dr Gary Mirams

Institution: 

  • University of Oxford
  • Strategic grant