Development of a New Human Model of Lung Squamous Cell Carcinoma Progression
Principal Investigator:
Dr Carlos Lopez-Garcia
Institution:
- University of Manchester
- Project grant
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Validation of an in vitro humanised 3D haematopoietic system to investigate haematological malignancies.
Principal Investigator:
Professor Helen Wheadon
Institution:
- University of Glasgow
- Project grant
Refinement of tickling protocols to improve positive animal welfare in laboratory rats
Principal Investigator:
Professor Alistair Lawrence
Institution:
- Scotland’s Rural College
- Project grant
Defining drug delivery into and across the oral mucosa using a tissue engineering and mathematical modelling approach
Principal Investigator:
Professor Craig Murdoch
Institution:
- University of Sheffield
- Project grant
Reducing and replacing the animal cost of functional genetics in African trypanosomiasis
Principal Investigator:
Dr Catarina Gadelha
Institution:
- University of Nottingham
- Project grant
Live monitoring of foreign-body response in animals by diffuse Raman spectroscopy
Principal Investigator:
Professor Ioan Notingher
Institution:
- University of Nottingham
- Project grant
Establishing Drosophila melanogaster as part of the pre-clinical pipeline for anti-metastatic cancer drug discovery
Principal Investigator:
Dr Kyra Campbell
Institution:
- University of Sheffield
- Project grant
Go North: Expanding the use of the chick embryo model in cancer research to a multiuser facility at the University of Strathclyde.
Principal Investigator:
Dr Anne Herrmann
Institution:
- University of Liverpool
- Skills and Knowledge Transfer grant
Acquisition of the Drosophila model system to understand mechanisms of innate immunity regulation by chromatin dynamics
Principal Investigator:
Dr Patrick Varga-Weisz
Institution:
- University of Essex
- Skills and Knowledge Transfer grant
Determining the efficacy and safety of cancer chemotherapeutics for cholangiocarcinoma (CCA) using Human Precision Cut Tissue Slices (hPCTS).
Principal Investigator:
Dr Laura Randle
Institution:
- Liverpool John Moores University
- Skills and Knowledge Transfer grant
Establishing the novel ex-vivo focal demyelination model of Multiple Sclerosis in other laboratories to reduce and replace live animal use.
Principal Investigator:
Dr Ben Newland
Institution:
- Cardiff University
- Skills and Knowledge Transfer grant
Adoption of a mouse model of veterinary filariasis for preclinical drug testing
Principal Investigator:
Dr Joseph Turner
Institution:
- Liverpool School of Tropical Medicine
- Skills and Knowledge Transfer grant
A non-protected larval zebrafish model for the investigation of novel strategies to protect against nerve agent-induced toxicity and seizures
Principal Investigator:
Dr Matthew Parker
Institution:
- University of Portsmouth
- Skills and Knowledge Transfer grant
Cerebral organoid models for optical investigation of neural circuit dynamics in neurodegenerative diseases
Principal Investigator:
Professor Simon Schultz
Institution:
- Imperial College London
- Skills and Knowledge Transfer grant
Transfer of an in vitro model for the evaluation of anticoccidial compounds
Principal Investigator:
Dr Virginia Marugan-Hernandez
Institution:
- Royal Veterinary College
- Skills and Knowledge Transfer grant
Replacing in vivo models with the Quasi vivo system to investigate metastatic site priming by tumour cells
Principal Investigator:
Dr Hannah Harrison
Institution:
- University of Manchester
- Skills and Knowledge Transfer grant
CleanCut - Developing a human in vitro model to assess the safety of gene edited human haemopoietic stem cells
Contractor:
Dr Alessandro Rotilio, MOAB srl
- CRACK IT Challenge
Transgene Track - An imaging approach to track AAV gene therapies and CAR T-cells in vivo
Contractor:
Professor Wolfgang Weber, Technical University of Munich
- CRACK IT Challenge
ImmuLiver – An immunologically-competent in vitro model of the human liver for the assessment of Yellow Fever vaccine attenuation
Contractor:
Professor Lyle Armstrong, Newcells Biotech Ltd
- CRACK IT Challenge
RaTS - Developing a device for objective monitoring of rheumatoid arthritis progression in rodents
Contractor:
Associate Professor Martin Hedegaard, University of South Denmark (SDU)
- CRACK IT Challenge
Generation of functionally mature pancreatic organoids as a replacement strategy for animal-models of pancreatitis and pancreatic cancer
Principal Investigator:
Dr Jean-Francois Darrigrand
Institution:
- King's College London
- Fellowship
Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage
Principal Investigator:
Dr Siobhan Crilly
Institution:
- University of Manchester
- Fellowship
Preclinical Radiomics: A novel approach linking imaging with biological outcomes in mouse models
Principal Investigator:
Dr Kathryn Brown
Institution:
- Queen's University Belfast
- Fellowship
Optimisation and validation of 3D models of progressive human lung fibrosis
Principal Investigator:
- Dr Joseph Bell
Institution:
- University of Southampton
- Fellowship
Supporting the adoption of microphysiological systems for COVID research
Current contact:
Dr Anthony Holmes
- Office-led project