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Insects as models to study the impact of antibiotics and microbiota therapies on the human gut microbiome: reducing the use of animals in research

Institution: 

  • John Innes Centre
  • PhD Studentship

Galleria mellonella - a novel infection model for Mycobacterium tuberculosis aimed at reducing the number of animals in experimentation

Institution: 

  • Imperial College London
  • PhD Studentship

Developing and validating a computational model of the gut microbiota-mucosa interactions to replace and reduce animal experiments

Institution: 

  • University of Birmingham
  • PhD Studentship

Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens

Institution: 

  • Swansea University
  • PhD Studentship

Refining, reducing and replacing non-model amphibian experiments on amphibian infectious diseases

Institution: 

  • Zoological Soc London Inst of Zoology
  • PhD Studentship

Using zebrafish embryos to identify genes that protect against atherosclerosis

Institution: 

  • University of Sheffield
  • PhD Studentship

Moving the Adverse Outcome Pathways Framework towards Practical Utility by Integrating Compound Profiling Data and Using Deep Learning

Institution: 

  • University of Cambridge
  • PhD Studentship

Replacing animal models in fungal pathogen research: An in vitro Titan virulence assay for the human fungal pathogen Cryptococcus neoformans

Institution: 

  • University of Birmingham
  • PhD Studentship

Validating the cross-species comparative in silico platform (CRISP)

  • CRACK IT Solution

3D hiPSC derived laminated retinal model as a tool for toxicology studies

  • CRACK IT Challenge

Microfluidic Automated Platform for Osteoarthritis Drug Screening (MA-PODS)

  • CRACK IT Challenge

Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel

Institution: 

  • Brunel University
  • Strategic grant

A chicken primary B cell culture model to study the pathogenesis and improve the control of immunosuppressive viruses of poultry

Institution: 

  • The Pirbright Institute
  • Project grant

Ex vivo model for the study of epicardium-targeted therapies

Institution: 

  • University of Surrey
  • Project grant

A comprehensive in silico approach to measure spatio-temporal changes of bone tissue in mouse models of osteoporosis and osteoarthritis

Institution: 

  • University of Sheffield
  • Project grant

Replacing liver cancer models by modeling human liver cancer in vitro

Institution: 

  • University of Cambridge
  • Project grant

Human Tissue for Safety Pharmacology

  • Office-led project

Improving the predictive power of models for cancer research

  • Office-led project

High-throughput in vitro culture system for Cryptosporidium oocysts: replacing animals in research

Institution: 

  • Cardiff University
  • Skills and Knowledge Transfer grant

The use of PrP transgenic Drosophila to replace and reduce mice in the bioassay of mammalian prions

Institution: 

  • University of Cambridge
  • Skills and Knowledge Transfer grant

Using chicken eggs to advance the 3Rs in cancer drug discovery

  • CRACK IT Solution

Integrated web platform for agro-chemical formulation toxicity classification and data sharing

  • CRACK IT Challenge

Neuroinflammation and nociception in a dish

  • CRACK IT Solution

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