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Developing alternative models to evaluate the impact of nanomaterials on neutrophils during the stimulation and resolution of inflammation

Institution: 

  • Heriot-Watt University
  • Project grant

Human tissue models for lung disease

Institution: 

  • Imperial College London
  • Infrastructure grant

In silico human-based methodologies for evaluation of drug cardiac safety and efficacy

Institution: 

  • University of Oxford
  • Infrastructure grant

Affimers: animal free alternatives to antibodies

  • CRACK IT Solution

A novel product for reducing animal numbers in the production of transgenic mice

  • CRACK IT Solution

ZeGlobalTox: multi-organ toxicity testing in zebrafish

  • CRACK IT Solution

NephroScreen: toxicity screening with a human renal cell line in a perfused titerplate

  • CRACK IT Challenge

Improving the predictive capacity of in vitro cytokine release assays to reduce animal use and drug attrition

  • CRACK IT Challenge

NeuroScreen-3D: microfluidic microtiter plates for in vitro neurotoxicity screening

  • CRACK IT Challenge

Differentiating alveolar macrophage responses to inhaled medicines

  • CRACK IT Challenge

A multiscale model to minimise animal usage in Leishmaniasis drug development

  • CRACK IT Challenge

A new Drosophila-based strategy to study mitochondrial transport and neuronal ageing in vivo

Institution: 

  • King's College London
  • Fellowship

Developing an Organ on a Chip Model to Test the Therapeutic Efficacy of Adhirons in Breast Cancer

Institution: 

  • University of Leeds
  • PhD Studentship

Development of functional 3D human intestinal mucosae to replace rodent models and improve the predictive accuracy of existing in vitro systems

Institution: 

  • Durham University
  • PhD Studentship

Developing a Drosophila melanogaster model of the cardiac myocyte action potential to investigate function and performance

Institution: 

  • University of Sussex
  • PhD Studentship

Development of a novel cell based bitter taste assessment assay

Institution: 

  • Aston University
  • PhD Studentship

Building brains in a dish - using ES cells to understand brain development

Institution: 

  • University of Edinburgh
  • PhD Studentship

Development and characterisation of a human ex vivo model of aneurysm

Institution: 

  • University of Bristol
  • PhD Studentship

Developing Human Glioma OrganDot Cultures

Institution: 

  • Cardiff University
  • PhD Studentship

Refining an in vitro system of predictive biomarkers of in vivo liposome efficacy

Institution: 

  • Aston University
  • PhD Studentship

Microfluidic networks: an in vitro 3D culture system for the investigation of neuron-glial interactions in neurodegeneration

Institution: 

  • University of Nottingham
  • PhD Studentship

Using zebrafish for pre-clinical brain haemorrhage research

Institution: 

  • University of Manchester
  • PhD Studentship

Untangling tauopathies: A microfluidics based drug-screening platform for human tau mutation neurons

  • CRACK IT Challenge

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