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Development of an AOP for cardiotoxicity mediated by the blockade of L-type calcium channel

Institution: 

  • Brunel University
  • Strategic grant

Opportunities to apply the 3Rs in the safety assessment of nanomaterials

  • Office-led project

Adoption of the Fixed Concentration Procedure for acute inhalation studies

  • Office-led project

Applying pathways-based approaches across the biosciences

  • Office-led project

Imprecision and importance: Probabilistic graphical models in toxicology

Principal Investigator: 

  • Dr Jonathan Pitchford

Institution: 

  • University of York
  • Strategic grant

Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs

Principal Investigator: 

  • Dr Michael Chappell

Institution: 

  • University of Warwick
  • Strategic grant

Uncertainty and confidence in applying mathematical models and in vitro data in toxicological safety assessments

Principal Investigator: 

  • Dr John Gosling

Institution: 

  • University of Leeds
  • Strategic grant