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Development of a New Human Model of Lung Squamous Cell Carcinoma Progression

Institution: 

  • University of Manchester
  • Project grant

Validation of an in vitro humanised 3D haematopoietic system to investigate haematological malignancies.

Institution: 

  • University of Glasgow
  • Project grant

Refinement of tickling protocols to improve positive animal welfare in laboratory rats

Institution: 

  • Scotland’s Rural College
  • Project grant

Defining drug delivery into and across the oral mucosa using a tissue engineering and mathematical modelling approach

Institution: 

  • University of Sheffield
  • Project grant

Reducing and replacing the animal cost of functional genetics in African trypanosomiasis

Institution: 

  • University of Nottingham
  • Project grant

Live monitoring of foreign-body response in animals by diffuse Raman spectroscopy

Institution: 

  • University of Nottingham
  • Project grant

Establishing Drosophila melanogaster as part of the pre-clinical pipeline for anti-metastatic cancer drug discovery

Institution: 

  • University of Sheffield
  • Project grant

Go North: Expanding the use of the chick embryo model in cancer research to a multiuser facility at the University of Strathclyde.

Institution: 

  • University of Liverpool
  • Skills and Knowledge Transfer grant

Acquisition of the Drosophila model system to understand mechanisms of innate immunity regulation by chromatin dynamics

Institution: 

  • University of Essex
  • Skills and Knowledge Transfer grant

Determining the efficacy and safety of cancer chemotherapeutics for cholangiocarcinoma (CCA) using Human Precision Cut Tissue Slices (hPCTS).

Institution: 

  • Liverpool John Moores University
  • Skills and Knowledge Transfer grant

Establishing the novel ex-vivo focal demyelination model of Multiple Sclerosis in other laboratories to reduce and replace live animal use.

Institution: 

  • Cardiff University
  • Skills and Knowledge Transfer grant

Adoption of a mouse model of veterinary filariasis for preclinical drug testing

Institution: 

  • Liverpool School of Tropical Medicine
  • Skills and Knowledge Transfer grant

A non-protected larval zebrafish model for the investigation of novel strategies to protect against nerve agent-induced toxicity and seizures

Institution: 

  • University of Portsmouth
  • Skills and Knowledge Transfer grant

Cerebral organoid models for optical investigation of neural circuit dynamics in neurodegenerative diseases

Institution: 

  • Imperial College London
  • Skills and Knowledge Transfer grant

Transfer of an in vitro model for the evaluation of anticoccidial compounds

Institution: 

  • Royal Veterinary College
  • Skills and Knowledge Transfer grant

Replacing in vivo models with the Quasi vivo system to investigate metastatic site priming by tumour cells

Institution: 

  • University of Manchester
  • Skills and Knowledge Transfer grant

Transgene Track - An imaging approach to track AAV gene therapies and CAR T-cells in vivo

  • CRACK IT Challenge

RaTS - Developing a device for objective monitoring of rheumatoid arthritis progression in rodents

  • CRACK IT Challenge

Generation of functionally mature pancreatic organoids as a replacement strategy for animal-models of pancreatitis and pancreatic cancer

Institution: 

  • King's College London
  • Fellowship

Understanding brain regeneration in a zebrafish larval model of intracerebral haemorrhage

Institution: 

  • University of Manchester
  • Fellowship

Preclinical Radiomics: A novel approach linking imaging with biological outcomes in mouse models

Institution: 

  • Queen's University Belfast
  • Fellowship

Optimisation and validation of 3D models of progressive human lung fibrosis

Principal Investigator: 

  • Dr Joseph Bell

Institution: 

  • University of Southampton
  • Fellowship

Supporting the adoption of microphysiological systems for COVID research

  • Office-led project

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