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Replacement
Refinement
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Activity type
Office-led project
Grants
- Project grant
- Pilot study grant
- Infrastructure grant
- Strategic grant
- Skills and Knowledge Transfer grant
- Technologies to Tools grant
Training
- PhD Studentship
- Fellowship
CRACK IT
- CRACK IT Challenge
- CRACK IT Solution
A highly sensitive replacement assay for botulinum neurotoxin type B
Principal Investigator:
Professor Bazbek Davletov
Institution:
University of Sheffield
Project grant
The role of water chemistry in zebrafish welfare and reproducibility of research studies
Principal Investigator:
Professor Roderic Wilson
Institution:
University of Exeter
Project grant
A novel murine model of squamous lung cancer
Principal Investigator:
Dr Frank McCaughan
Institution:
University of Cambridge
Project grant
Development and evaluation of the Animal Welfare Assessment Grid (AWAG)
CRACK IT Solution
Implementation of non-aversive mouse handling for welfare refinement and reduction of mouse numbers
Principal Investigator:
Dr John Roughan
Institution:
Newcastle University
Skills and Knowledge Transfer grant
The Refining Dog Care online learning platform - a modular learning resource for those working with dogs in research
Principal Investigator:
Dr Laura Scullion Hall
Institution:
University of Stirling
Skills and Knowledge Transfer grant
Using wireless recording technologies to investigate cortical coherence in a mouse model of dementia
Principal Investigator:
Dr Jonathan Brown
Institution:
University of Exeter
Skills and Knowledge Transfer grant
RespiraTox: In silico model for predicting human respiratory irritation
Contractor:
Dr Sylvia Escher, Fraunhofer ITEM
CRACK IT Challenge
A new sensor platform combining plastic antibodies with simple thermal detection
CRACK IT Solution
Multiphoton imaging in human liver tissues: validation of a new tool for drug discovery
Principal Investigator:
Dr Scott Davies
Institution:
University of Birmingham
Fellowship
Novel approach to model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells
Principal Investigator:
Dr Carola Morell
Institution:
University of Cambridge
Fellowship
Drosophila model for muscular pain
Principal Investigator:
Dr Olga Baron
Institution:
King's College London
Fellowship
Development of the chick embryo as a replacement for rodent models of tumour metastasis
Principal Investigator:
Dr Anne Herrmann
Institution:
University of Liverpool
Fellowship
Revision of the ARRIVE guidelines
Current contact:
Dr Nathalie Percie du Sert
Office-led project
Development of E-Sense: a flexible in vitro platform to determine cardiovascular risk
Principal Investigator:
Dr Stephen White
Institution:
Manchester Metropolitan University
PhD Studentship
Characterising Mycobacterium tuberculosis in the human lung; developing new tools for antimicrobial drug discovery through the SH-TBL clinical trial
Principal Investigator:
Dr Simon Waddell
Institution:
University of Sussex
PhD Studentship
An alternative approach for assessing drug-induced seizures, using non-protected larval zebrafish
Principal Investigator:
Professor Charles Tyler
Institution:
University of Exeter
PhD Studentship
Generating in vitro human optic vesicles to dissect the genetic modifiers affecting ocular maldevelopment
Principal Investigator:
Dr Mariya Moosajee
Institution:
University College London
PhD Studentship
Insects as models to study the impact of antibiotics and microbiota therapies on the human gut microbiome: reducing the use of animals in research
Principal Investigator:
Professor Anthony Maxwell
Institution:
John Innes Centre
PhD Studentship
Galleria mellonella - a novel infection model for Mycobacterium tuberculosis aimed at reducing the number of animals in experimentation
Principal Investigator:
Professor Paul Langford
Institution:
Imperial College London
PhD Studentship
Developing and validating a computational model of the gut microbiota-mucosa interactions to replace and reduce animal experiments
Principal Investigator:
Dr Jan-Ulrich Kreft
Institution:
University of Birmingham
PhD Studentship
Developing an in vitro repeat-dose test as a 3Rs approach to detect non-genotoxic carcinogens
Principal Investigator:
Professor Gareth Jenkins
Institution:
Swansea University
PhD Studentship
Recreating thrombosis models using tissue-engineered arterial constructs: A novel method to reduce and replace mice used in platelet research
Principal Investigator:
Dr Alan Harper
Institution:
Keele University
PhD Studentship
Refining, reducing and replacing non-model amphibian experiments on amphibian infectious diseases
Principal Investigator:
Dr Trenton Garner
Institution:
Zoological Soc London Inst of Zoology
PhD Studentship
Using zebrafish embryos to identify genes that protect against atherosclerosis
Principal Investigator:
Professor Paul Evans
Institution:
University of Sheffield
PhD Studentship
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