Structural identifiability and indistinguishability analysis as tools for quantitative and systems pharmacology to support the 3Rs

This proposal aims to overcome recognised limitations in the modelling of toxicological processes by introducing and applying established and novel systems modelling tools and techniques to exemplar problems in toxicology. The project will provide a more robust generic analytical framework to improve parameter estimation, sensitivity, robustness, reliability and validity of models in toxicology. In turn this step change in modelling will enhance experiment design, improve risk and safety assessment and thus help support the 3Rs of animal use. This research will be supported by industry (AstraZeneca) and will be applied to models for the improvement of both human and animal safety. This work will provide new tools and seed the emergence of a new field, namely quantitative and systems toxicology.

Collins TA, Bergenholm L, Abdulla T, Yates J, Evans N, Chappell MJ, Mettetal JT (2015). Modeling and simulation approaches for cardiovascular function and their role in safety assessment. CPT Pharmacometrics Syst Pharmacol. 4(3):e00018. doi: 10.1002/psp4.18. 

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Strategic grant

Status:

Closed

Principal investigator

Dr Michael Chappell

Institution

University of Warwick

Co-Investigator

Dr Neil Evans

Grant reference number

NC/K001205/1

Award date:

Apr 2013 - Apr 2016

Grant amount

£245,378 (Co-funded by EPSRC)