Tox News: Issue 5, February 2019


Register for the NC3Rs/Unilever studentship launch event 2 April 2019


Up to three NC3Rs PhD studentships will be co-funded with Unilever in 2019 as part of a new collaboration within the field of non-animal safety assessment. This launch event will allow potential applicants to find out more about the scheme, network with fellow researchers and discuss ideas with staff from both Unilever and the NC3Rs.


Attendance is free, but registration is essential. The closing date for registration is 27 March 2019.




Tox Team welcomes new Science Manager


Dr Briony Labram has joined the Toxicology and Regulatory Sciences team as a Science Manager. Prior to joining the NC3Rs, Briony worked at the MHRA after completing her PhD in Regenerative Medicine at the University of Manchester.




Promoting the 3Rs internationally


NC3Rs Programme Managers Dr Fiona Sewell and Dr Helen Prior attended the 4th International Conference on Toxicity Testing Alternatives and Translational Toxicology (TATT) (Guangzhou, China) in October 2018, which aimed to discuss and promote worldwide research developments and application of toxicity testing alternatives and translational toxicology.


Scientific advances and technologies are progressing rapidly within China, supported by funding for academia and a willingness from regulators to consider alternatives to animal methods. Fiona gave a plenary lecture, 'Evidence-building to influence changes in regulations and guidelines: pioneering better science by applying the 3Rs' during the conference.



The NC3Rs co-organised a symposium, 'Integration of consortia recommendations for justification of animal use within current and future drug development paradigms', at the American College of Toxicology (ACT) 39th Annual Meeting (Palm Beach, USA) in November 2018. Professor Ian Kimber OBE chaired the session and Helen presented results from the NC3Rs/ABPI working group project 'Review of the use of a second species in regulatory studies'. We also presented two posters with further results from the project and had a booth in the exhibit space, which proved to be a great place to meet existing contacts and make new ones.




Helen elected to Safety Pharmacology Society (SPS) Board


Helen has been Secretary to the SPS for the past two years. The SPS is a non-profit organisation that promotes knowledge, development, application, and training in safety pharmacology and Helen is an active member of the society. The NC3Rs has several collaborations with the SPS and we are delighted that whilst her term as Secretary has ended, she has been elected as a Board member for a further two year term.




Opportunities to meet members of the NC3Rs Tox Team and find out more about our work at conferences and events over the upcoming months.


Find a full list of NC3Rs events on our website calendar.



Society of Toxicology (SOT) 58th Annual Meeting and ToxExpo


10-14 March 2019 (Baltimore, Maryland)


On Tuesday 12 March Fiona will present poster P510, 'Are we fully exploiting the use of a single species for post-'first-in-human' (FIH) studies allowed within ICH S6?', in the session 'Safety Assessment Pharmaceutical: Drug Development'. There will also be a poster (P759), 'Evaluation of Trularv as a Model Host for Assessment of Acute Toxicity of Chemicals', focusing on the TruLarv™ CRACK IT Solution. This will be presented on Wednesday 13 March in the session 'Alternatives to Mammalian Models III'.


We will also have a stand within the ToxExpo (booth 2306). Come along and say hello to Fiona and Nikki!




Data Sciences International (DSI) 2019 European User Group Meeting


28-29 March 2019 (Berlin, Germany)


The DSI User Group meeting is held bi-annually and is attended by industry and academic scientists using in vivo models in preclinical research. Helen will be speaking about 'Social housing and telemetry in rodents and non-rodents' in the afternoon session of Friday 29 March.




RSPCA Challenging Refinements


4 April 2019 (Stevenage, UK)


This one day meeting will feature practical case studies of successful refinements to procedures where this is traditionally regarded as challenging; for example, analgesia provision in pain models, or refining humane endpoints in some regulatory tests. As part of this one day meeting Fiona will be presenting a talk, 'Use of evident toxicity to replace death as an endpoint'.




British Toxicology Society (BTS) Annual Congress 2019


15-17 April 2019 (Cambridge, UK)


Registration is now open to attend the BTS Annual Congress, which this year is being held jointly with the United Kingdom Environmental Mutagen Society (UKEMS). Fiona will be co-chairing a NC3Rs-sponsored symposium (Symposium 9, Wednesday 17 April) and Helen will present a talk, 'NC3Rs/ABPI review of two species uses: can we further exploit ICHS6 opportunities for one species?'. We also have a booth in the trade exhibition area so come and say hello to the team.



15th International Congress of Toxicology ICTXV


15-18 July 2019 (Honolulu, Hawaii)


The ICT is held every three years, with the next one being held by the International Union of Toxicology (IUTOX) in partnership with SOT. The preliminary schedule is now available for this conference. Helen will be speaking during the session 'Collaborative Approaches to Proactively Advance 3Rs in Nonclinical Drug Development' and Fiona and Nikki will be presenting posters (abstract numbers 0158 and 0722) on Tuesday 16 July on advancing the 3Rs for pharmaceuticals and in acute toxicity testing.



A list of all NC3Rs publications in Toxicology and Regulatory Sciences can be found in our bibliography. New publications co-authored by NC3Rs staff include:

  • Prior H, Casey W, Kimber I, Whelan M, Sewell F (2019). Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals. Regulatory Toxicology and Pharmacology 102 30-33. doi: 10.1016/j.yrtph.2018.12.008

  • Skinner M, Ceuppens P, White P, Prior H (2019). Social-housing and use of double-decker cages in rat telemetry studies. Journal of Pharmacological and Toxicological Methods 96: 87-94. doi: 10.1016/j.vascn.2019.02.005


NC3Rs/Unilever workshop: Application of non-animal approaches for decision making in chemical safety assessment


Last year we jointly hosted a scientific workshop with Unilever to explore the application of non-animal approaches for decision making in chemical safety assessment. It was well attended with over 90 delegates and speakers from industry (agrochemicals, industrial chemicals, pharmaceuticals, cosmetics and consumer products), academia and regulatory agencies from 14 countries. The slides presented are now available on our website.




Guest lectures in university courses


We continue to contribute towards educating the next generation of scientists by lecturing at universities.

  • Fiona recently was a guest lecturer for undergraduate Biomedical Science students at St George's, University of London.

  • Helen visited Birmingham University to give a lecture to MSc Toxicology students.


Subscribe to Tech3Rs: a newsletter for animal technicians


Tech3Rs is our regular newsletter providing animal technicians with the latest news from the NC3Rs. Each issue features updates on recent advances in the 3Rs and highlights new resources, research and events that we think will be of interest to animal technicians. Tech3rs is available to download from our website, and we also post out hard copies of the newsletter to UK research facilities.




Tox Team presentations


In addition to TATT and ACT, the Tox Team have a busy few months travelling to other scientific meetings to disseminate project results including: