Validating reward-related behaviour for welfare assessment, and improving welfare through increased predictability of events

Animal welfare can be measured on a scale of poor to good, and will at any one point reflect the balance of their positive and negative affective states. Behaviour is the most accessible measure of welfare, being the result of all the animal's own individual decision making processes and also expressing their emotions. By measuring anticipatory behaviour to announced rewards, we can determine an animal's reward sensitivity, which reflects the brain's evaluation of its subjective state and the environment. Behavioural activation in anticipation of a reward involves mesolimbic dopaminergic systems; these systems are known to be sensitized by stressors suggesting the biological mechanism underlying the use of such behaviour in welfare assessment. The animal is adapted to select the most efficient (i.e. most rewarding) response, and those with more stress will show higher levels of anticipatory behaviours for a reward, whilst those with positive experiences with have less anticipatory behaviour. The first goal is to validate this measure, with a battery of other welfare measures in macaques and dogs in a working laboratory environment, to show practicality. The second goal is to manipulate signalled predictability to inform laboratory animals of what will happen to them. Evidence strongly suggests that animals prefer predictable events, be they positive (e.g. appetitive) or negative. Knowing, through a reliable signal which can be classically conditioned over paired trials, when events will happen is good for welfare (the preparatory hypothesis), and also informs animals when they are safe (the safety signal hypothesis). The project will systematically investigate and validate this new welfare assessment tool, and assess an associated Refinement that is cost effective, requires no changes to the physical infrastructure, and can be implemented widely to improve welfare and reduce the adverse impact of procedures, with potential to improve the quality of scientific output.

Scullion-Hall LE, Robinson S, Finch J, Buchanan-Smith HM (2016). The influence of facility and home pen design on the welfare of the laboratory-housed dog. J Pharmacol Toxicol Methods 83: 21-29 doi: 10.1016/j.vascn.2016.09.005 

 

Back to top
Project grant

Status:

Closed

Principal investigator

Professor Hannah Buchanan-Smith

Institution

University of Stirling

Grant reference number

NC/K000101/1

Award date:

Apr 2013 - Nov 2015

Grant amount

£168,345