Candida albicans is a human commensal organism that can cause life-threatening systemic infections in severely ill patients. The mouse intravenous challenge model is commonly used to model this infection. However, recent research has found that it is early events in the kidney that generate damaging immune responses and determine gross outcome of infection. Therefore, identification of the renal cells involved in these responses will allow development of an in vitro assay to model these events.
Mackie J et al. (2016). Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections. PloS One 11(6):e0158683. doi: 10.1371/journal.pone.0158683
Szabo EK and MacCallum DM (2014). A novel renal epithelial cell in vitro assay to assess Candida albicans virulence. Virulence 5(2):286-96. doi: 10.4161/viru.27046
Szabo EK and MacCallum DM (2011). The contribution of mouse models to our understanding of systemic candidiasis. FEMS Microbiol Lett 320(1):1-8. doi:10.1111/j.1574-6968.2011.02262.x
- Catalyst magazine article: Skin deep: modelling fungal skin infections
- 2017 PhD Studentship Review: Case Study
- Further Funding: NC3Rs PhD Studentship, Reducing animal usage in antifungal drug development: iRFP reporter strains and imaging infection, October 2016, £90,000
- Further Funding: NC3Rs Pilot Study Grant, Live real-time imaging of life-threatening invasive fungal infections, July 2013, £76,139