ARRIVE guidelines survey
Seven years after publication we are reviewing how our ARRIVE guidelines are used and their impact on the reporting of animal experiments.
Applying bioprinting to safety testing
Improving drug and chemical product development, replacing the use of animals.
Approaches to monkey chair restraint: a survey
Findings include recommendations for refining training and procedures.
£2.7m awarded to nine new project grants
Includes two awards focusing on applying the 3Rs to poultry research.
Improving data management to benefit the 3Rs
AstraZeneca’s PreDICT project on improving data management from in vivo experiments.
Highlight notice: approaches to ageing research
A joint funding highlight notice between the BBSRC and NC3Rs.
Our strategy
Plans to tackle the gap between the development and uptake of 3Rs methods
2017: The NC3Rs year of laboratory rodent welfare
In 2017 we will run a number of initiatives focusing on the welfare of laboratory rodents.
Collecting DNA from zebrafish
New project explores a non-invasive DNA collection technique, improving fish welfare.
2017 CRACK IT Challenges launch
Register now for this year's CRACK IT Challenges launch event taking place on 7 September in London.
Our PhD Studentship Review
A new review from the NC3Rs, focusing on the scientific and 3Rs impacts of our PhD studentship scheme to date.
Public engagement awards scheme: open rolling call
Grant holders can apply for an award of up to £1,500 to engage the public in 3Rs research.

The NC3Rs

If you are a scientist, animal technician, veterinarian, regulator, funder or policy maker, the NC3Rs can help you to:

  • Drive scientific and technological developments that replace, reduce or refine the use of animals in research (the 3Rs)
  • Ensure your animal experiments are as robust and reproducible as possible
  • Provide the best welfare for laboratory animals


Science-led and evidence-based, we fund research and early careers, foster collaborations between universities and industry to develop and commercialise 3Rs technologies, and provide information on the latest advances to put the 3Rs into practice.

Keep in touch

Latest news

IMPROVE-ing animal welfare in experimental stroke research

New guidelines set out 43 recommendations for best practice for the most commonly used mouse and rat stroke models. 

First ever survey of approaches to monkey chair restraint

Findings show there is a need for the non-human primate research community to work together to refine chair restraint procedures, and provide recommendations for refinement.

2017 CRACK IT Challenges announced

The 2017 CRACK IT Challenges competition consists of three Challenges in the area of toxicology.

NC3Rs in Seattle

Presentations, posters and workshops from the NC3Rs team at the World Congress on Alternatives in Seattle. If you're attending the conference in August, come and see us.

£2.7m awarded to nine new project grants

The latest project grant funding from the NC3Rs includes two awards focusing on applying the 3Rs to poultry research.

Bridging the 3Rs "valley of death": the NC3Rs strategy 2017 to 2019

Our strategy sets out our plans for the next three years (2017 - 2019) with initiatives to drive forward the 3Rs.

Investigating social stimuli as rewards in macaque neuroscience

Scientists at Newcastle University have explored the use of social stimuli as a potential alternative to fluid restriction.

Refining training methods for macaques in neuroscience research

New robust and inexpensive system allows unsupervised and voluntary training of macaques while they are housed in social groups.

Reducing the use of male Xenopus frogs

Researchers at University of Portsmouth have optimised a robust sperm preservation method that will reduce the number of frogs used in research.

Latest blogs

A new partnership with F1000Research

Publishing methodological details and 3Rs impacts from NC3Rs grants.

Data, data, data: The importance of measurement and the 3Rs

The first in a series of guest blogs looking at different aspects of data management and its importance for the 3Rs.  

Impressions from Pint of Science 2017

Read the impressions from four NC3Rs-sponsored events during this year's Pint of Science festival.  

Funding for PhD studentships in cardiovascular research

This year we have funding for three PhD studentships as part of our collaboration with the British Heart Foundation.

STEM for Britain: researchers visit the Parliament

NC3Rs-funded PhD student Neal Rimmer shares his experience of participating in STEM for Britain, a competition for early career researchers to present their work in the House of Commons.

How serious are we about asepsis for rodent surgery?

A blog from Professor Paul Flecknell from Newcastle University, discussing aseptic surgery.

Eleven ways your funding application could be failing

Tips from the NC3Rs funding team on avoiding common pitfalls when writing a grant application.  

Announcing the NC3Rs year of laboratory rodent welfare

We are launching a number of exciting initiatives in 2017 focusing on the welfare of rats and mice.