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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

Our reports and reviews

Reports, reviews and publications highlighting the 3Rs impacts of our work.

Report 2025: Incorporating new approach methodologies in the development of new medicines

A report from the NC3Rs, in collaboration with the ABPI and MHRA, exploring how New Approach Methodologies (NAMs) can transform the way new medicines are developed – harnessing cutting edge human relevant technologies and reducing reliance on animal testing.

The joint report describes insights from a cross-sector workshop convened by the NC3Rs, ABPI and MHRA, bringing together experts from regulatory agencies, industry and academia. Discussions focused on where NAMs are currently being used in medicines development, the scientific and regulatory challenges to broader adoption, and practical steps to accelerate progress.

Read more in our news item: Incorporating NAMs into medicines development: Insights from regulators, industry and academia.


Briefing paper 2025: Improving translation and minimising animal use with human-relevant in vitro preclinical models
 

Over the past 20 years the NC3Rs has focused on replacing studies that involve large numbers of animals, high levels of animal suffering, or are poorly predictive in terms of their translatability or reproducibility. From a starting point of scientific excellence, we are developing the next generation of preclinical models and supporting the qualification, optimisation and uptake of in vitro alternatives. This briefing paper outlines our work in this area, driving forward human-based in vitro preclinical models.


Our Vision: 2015-2025

Setting out the NC3Rs vision for the next ten years, the publication is divided into five inter-related areas; Practice, Procedures, People, Places and Policy.


Evaluating progress in the 3Rs: the NC3Rs framework

Our approach to measuring 3Rs impact through a framework that evaluates inputs, and outputs, as well as interim and mature impacts.


2019 CRACK IT Review

Highlighting the work of ten teams involved in our CRACK IT programme which have produced 3Rs focused outputs that include prototypes, products and services.


2019 Research Review

Case studies highlighting the work of 12 NC3Rs-funded scientists, to illustrate the impact of their work on the 3Rs and the wider scientific context.


Historic publications