Wednesday 11 May 2016
A recent publication in the journal mAbs “Waiving in vivo studies for monoclonal antibody biosimilar development: National and global challenges” highlights ways to reduce animal use in the development of monoclonal antibody (mAb) biosimilars.
Thursday 28 April 2016
We are pleased to announce a new strategic award to Professor Alex Thiele, Newcastle University, for a project aimed at refining the design of cranial implants used in neuroscience studies with macaques, in order to improve the welfare of these animals.
Friday 22 April 2016
The NC3Rs and Safety Pharmacology Society (SPS) have just published the paper ‘Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies’. The report, available in the Journal of Pharmacological and Toxicological Methods, summarises a survey on current...
Wednesday 20 April 2016
The annual Pint of Science festival will be taking over pubs across the country next month to host evenings where scientists discuss their research over a proverbial pint. The NC3Rs has been participating in the festival since it was launched in 2013. This year we are sponsoring events in London, Southampton...
Wednesday 23 March 2016
A new study has shown that introducing physiologic cues to the in vitro culture of hepatocyte-like cells (HLCs) makes them a more relevant hepatocyte model that can be used in non-animal liver toxicity testing. The paper, published last week in Archives of Toxicology, is the result of a collaboration between...
Tuesday 15 March 2016
A study describes a new method to grow a drug resistant sub-population of cancer stem cells (CSCs) in vitro, providing an opportunity to screen compounds that target these cells using fewer animals.
Wednesday 09 March 2016
Three projects have each been awarded £30,000 seed funding, through the NC3Rs CRACK IT Solutions partnering programme, to support collaborations which will help develop, validate and test technologies with 3Rs potential. The programme links technology developers with researchers and organisations that can add...
New CRACK IT Solution: Extrapolating in vitro to in vivo toxicity for predicting effects on growth in rats and mice
Tuesday 08 March 2016
Researchers at the University of York are seeking partners with expertise in mammalian cell culture to develop novel mathematical approaches for in vitro to in vivo extrapolation. Such models developed as part of a suite of tests have the potential to reduce the use of animals in chronic toxicity studies. The...
Monday 29 February 2016
Three pieces of outstanding published research with 3Rs impacts have been given awards in this year’s 3Rs Prize competition, run by the NC3Rs, and sponsored by GlaxoSmithKline (GSK). The Prize ceremony is taking place today (29 February) with 150 guests from across the scientific community attending. The 3Rs...
Latest CRACK IT Challenges: funding innovative technologies with 3Rs benefits and business potential
Monday 29 February 2016
Six teams have been awarded funding in Phase 1 of the latest NC3Rs CRACK IT Challenges competition, a challenge-led competition run in collaboration with the UK’s innovation agency, Innovate UK, using its Small Business Research Initiative (SBRI). CRACK IT Challenges bring together industry, academia and SMEs...
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Our monthly newsletter provides the latest updates from the NC3Rs, including funding calls and events.