Better consideration of exposure within toxicological testing is necessary to ensure that the data generated are relevant to answer the scientific questions being asked. For example, measurement of internal test compound concentrations (toxicokinetics) can aid in dose setting for toxicology studies to ensure that doses causing overt toxicity are not used in test animals. Also, a greater understanding of exposure within new approach methodology test systems will support the translation of effects to in vivo situations - making these data more useful for decision-making purposes, and ultimately reducing the current reliance on data from animal tests.
Applying exposure science to increase the utility of non-animal data in efficacy and safety testing
Bringing together experts in the fields of exposure science, efficacy and toxicology to increase the uptake of non-animal approaches.