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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research
Pioneering better science

Replacement, Reduction and Refinement

A UK-based scientific organisation dedicated to helping the research community worldwide to identify, develop and use 3Rs technologies and approaches.
Our mission
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Guidelines, practical information, publications, video and training materials to help you put the 3Rs into practice.

Black mouse sitting on open hands. The technician is wearing a blue coveralls and blue medical grade gloves.

We fund world class researchers to develop predictive, reliable and humane 3Rs approaches.

Two scientists look into microscopes

Details of NC3Rs projects, including grants, early career awards and work led by our staff.

Two researchers look at a sample in a Petri dish

What are the 3Rs? How many animals are used in research? Find answers to these questions and more.

Two white rats in an enriched cage containing cardboard tunnels and paper towels.

Latest news

Funding of £1.2M is available through this year’s CRACK IT Challenges competition. The two 2022 Challenges encompass animal use in the key areas of endocrine disruption and CAR-T cell therapy.

T-ALERT and Thyroid Tox Challenge images
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Upcoming events

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Guidance

Developing and implementing an institutional 3Rs strategy

Guidance for those overseeing animal research at institutions on recognising 3Rs opportunities and putting them into practice.

Develop a strategy for your institution
A technician in PPE transfers a mouse from scales back to its cage via a plastic tunnel.