New ARRIVE guidelines 2.0 released
The guidelines and accompanying website will help researchers increase the reliability and reproducibility of animal studies through better reporting.
The NC3Rs and the 3Rs during COVID-19
An update on what we are doing to support the research community.
NC3Rs webinars
Register for our upcoming webinars and watch recordings of past presentations on a wide range of 3Rs topics.
Reducing animal use in the testing of biologicals
New project will review WHO guidelines to identify opportunities to incorporate non-animal testing approaches.
Could you lead our new biologicals project?
We are currently recruiting a Programme Manager to join our team.
Experimental design
Resources to help you improve the design and reporting of your in vivo research.
International 3Rs Prize awarded
Congratulations to this year's joint winners, Dr Francesca Nunn and Dr Marta Shahbazi.
3Rs for the public
Learn more about the 3Rs and their importance in research.
Join the NC3Rs Board
Apply for our current vacancies by 7 October and help shape our strategy.
CRACK IT Challenges 2020 announced
Read about this year's Challenges and register for our launch event webinars.
Tech3Rs: our animal technician newsletter
Sign up to receive free copies for UK facilities and stay up to date with the 3Rs.
Explore the evidence base for refined mouse handling
Our new printable table summarises the research published to date.

The NC3Rs: Pioneering better science


We help the research community use the latest science and technology to replace animal studies, providing new approaches for biomedical research and avoiding the time and cost associated with in vivo models. Where the use of animals is still required, we support researchers to design the best experiments so that their methods and findings are robust and reproducible. We provide information and guidance on the latest knowledge to improve laboratory animal welfare.

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Latest news

CRACK IT Challenges for 2020 announced

Up to £3.5 million funding is available to solve five Challenges identified jointly by the NC3Rs and Sponsors.

Six things we’ve learnt about the brain using 3Rs methods

Discover how NC3Rs Grant holders are using 3Rs methods to provide insights into neuroscience.

New ARRIVE guidelines 2.0 released

The updated guidelines will help researchers increase the reliability and reproducibility of animal studies through better reporting. 

A change in (cell) culture: exploring alternatives to fetal calf serum

Dr Jan van der Valk explores why fetal calf serum-free media are important and how the FCS-Free Database can support scientists.

Taking aim at the 3Rs

Dr Mark Prescott comments on recent publications advocating for the replacement of the 3Rs with a broader ethical framework.