2019 International 3Rs Prize: competition now open
The deadline to apply for this year's prize, sponsored by GSK, is 4pm on 6 March.
3Rs for the public
Learn more about the 3Rs and their importance in research.
Vacancies at the NC3Rs
Learn more about our current vacancies, including how to apply.
CRACK IT 2020: Call for Challenges
Could your organisation sponsor the next CRACK IT Challenge to improve R&D and reduce reliance on animal models?
Discover publications from NC3Rs researchers
Visit our open access publication portal, hosted by F1000Research.
Burrow into our citizen science project
Contribute to lab mouse welfare via this project, a collaboration with MRC Harwell.
Professor Kevin Shakesheff appointed as NC3Rs Board Chair
Expert tissue engineer and pharmacist is the new Chair of the NC3Rs Board.
Explore the NC3Rs Innovation Platform
Learn more about our CRACK IT programme and how you can get involved.
Experimental design
Resources to help you improve the design and reporting of your in vivo research.
Minimising aggression in group-housed male mice
Read the results of our international mouse aggression study, recently published in Scientific Reports.
Tech3Rs: our animal technician newsletter
Sign up to receive free copies for UK facilities and stay up to date with the 3Rs.
Explore the evidence base for refined mouse handling
Our new printable table summarises the research published to date.

The NC3Rs: Pioneering better science

If you are a scientist, animal technician, veterinarian, regulator, funder or policy maker, the NC3Rs can help you to:

  • Drive scientific and technological developments that replace, reduce or refine the use of animals in research (the 3Rs)
  • Ensure your animal experiments are as robust and reproducible as possible
  • Provide the best welfare for laboratory animals


Science-led and evidence-based, we fund research and early careers, foster collaborations between universities and industry to develop and commercialise 3Rs technologies, and provide information on the latest advances to put the 3Rs into practice.

Read more about the impacts of the science we support.

Keep in touch

Latest news & blogs

New article types on the NC3Rs gateway

We have added four new article types to our gateway on the F1000 platform to capture more of the research outputs from our grant holders.

Meet our newest Training Fellows

We have awarded four new NC3Rs Training Fellowships, totalling £512k, to support the development of talented 3Rs-minded postdoctoral researchers.

Making refinements a reality – why we can be proud

Animal technician Joanne King shares some of the refinements the University of Dundee's Medical School Resources Unit has put into practice over the last 18 months and how they've made a difference.

Changing mouse handling practice at a university establishment: an NTCO's perspective

Lesley Gilmour, NTCO at the University of Glasgow, shares her experience of implementing refined mouse handling across the institution.