Revision of the ARRIVE guidelines
The revised ARRIVE guidelines are now available in preprint – sign up as a roadtester and help shape their final development.
Burrow into our new citizen science project
Contribute to mouse welfare research via this project, a collaboration with MRC Harwell.
Vacancy: Animal Welfare Programme Manager
Applications for this one year fixed-term role close on Thursday 1 August.
Explore our new Innovation Platform website
We have transformed the CRACK IT website with a refreshed design and features that showcase our programmes and their outputs.
Tech3Rs: our animal technician newsletter
Sign up to receive free copies for UK facilities and stay up to date with the 3Rs.
2019 NC3Rs/IAT Animal Technicians’ Symposium
A chance for junior animal technicians to learn about the latest advances in refinement.
What are the 3Rs and why are they important?
Our video presentation has been designed for use in training and education.
Read our latest Research Review
The review profiles the work of 12 NC3Rs-funded scientists and its impacts on the 3Rs and beyond.
Discover publications from NC3Rs researchers
Visit our open access publication portal, hosted by F1000Research.
Explore the evidence base for refined mouse handling
Our new printable table summarises the research published to-date on tunnel handling and cupping methods.
Experimental design
Resources to help you improve the design and reporting of your in vivo research.
Single use needles: putting refinement into practice
Dr Sally Robinson explores how AstraZeneca has implemented the single use of needles.

The NC3Rs: Pioneering better science

If you are a scientist, animal technician, veterinarian, regulator, funder or policy maker, the NC3Rs can help you to:

  • Drive scientific and technological developments that replace, reduce or refine the use of animals in research (the 3Rs)
  • Ensure your animal experiments are as robust and reproducible as possible
  • Provide the best welfare for laboratory animals


Science-led and evidence-based, we fund research and early careers, foster collaborations between universities and industry to develop and commercialise 3Rs technologies, and provide information on the latest advances to put the 3Rs into practice.

Keep in touch

Latest news & blogs

Development of a new automated behaviour monitoring tool for zebrafish

The Fish Behaviour Index uses a camera and tracking software to assess how zebrafish behaviour changes in response to laboratory procedures.

A taste of Pint of Science 2019

We look back at the events we sponsored in Birmingham, London and Newcastle as part of Pint of Science 2019, which featured NC3Rs-funded researchers from a variety of fields speaking about their work.

Funding awarded for transfer of 3Rs approaches

The Skills and Knowledge Transfer scheme supports the exchange of models with 3Rs potential, including joint funding with Cancer Research UK.

Awards to accelerate translation of 3Rs technologies for industrial use

Our new Technologies to Tools scheme, a collaboration with Medicines Discovery Catapult, offers NC3Rs-funded researchers an opportunity to maximise the 3Rs impacts of their work.

Visit our new CRACK IT Innovation Platform website

The Innovation Platform will connect researchers across sectors and disciplines to accelerate the development, application and commercialisation of 3Rs technologies.