Vacancies at the NC3Rs
Learn more about our current vacancies, including how to apply.
Help us improve our online resources
Share your thoughts via our survey, which should take no more than five minutes.
Experimental design
Resources to help you improve the design and reporting of your in vivo research.
Read our 2019 CRACK IT Review
Explore the first eight years of our CRACK IT open innovation programme and its business, scientific and 3Rs impacts.
Discover publications from NC3Rs researchers
Visit our open access publication portal, hosted by F1000Research.
Burrow into our new citizen science project
Contribute to lab mouse welfare via this project, a collaboration with MRC Harwell.
2019 Challenges Competition is now open - Invitation to Tender
This year's competition consists of three Challenges identified jointly by the NC3Rs and Sponsors.
Tech3Rs: our animal technician newsletter
Sign up to receive free copies for UK facilities and stay up to date with the 3Rs.
Explore the evidence base for refined mouse handling
Our new printable table summarises the research published to date.
Reuse of needles hub
Find resources on the single use of needles and pre-order our new poster.
Explore the NC3Rs Innovation Platform
Learn more about our CRACK IT programme and how you can get involved.
What are the 3Rs and why are they important?
Our new video presentation has been designed for use in training and education.

The NC3Rs: Pioneering better science

If you are a scientist, animal technician, veterinarian, regulator, funder or policy maker, the NC3Rs can help you to:

  • Drive scientific and technological developments that replace, reduce or refine the use of animals in research (the 3Rs)
  • Ensure your animal experiments are as robust and reproducible as possible
  • Provide the best welfare for laboratory animals


Science-led and evidence-based, we fund research and early careers, foster collaborations between universities and industry to develop and commercialise 3Rs technologies, and provide information on the latest advances to put the 3Rs into practice.

Keep in touch

Latest news & blogs

Minimising aggression in group-housed male mice

The results of our crowdsourcing study to understand and minimise aggression in male mice are published in Scientific Reports.

Read our reports from international NC3Rs toxicology symposia

The two reports highlight how the 3Rs are being advanced in drug development internationally, as well as the progress of adopting non-animal methods for acute toxicity testing.

Meet the newest members of the NC3Rs Board

Our five new Board members will bring a wealth of expertise to their role, supporting the NC3Rs to deliver on its strategic goals.

£1.8 million awarded through 2019 NC3Rs Project Grant scheme

Five awards have been made this year to support the development of a diverse selection of 3Rs approaches.

New CRACK IT Review showcases our open innovation programme

Highlighting the work of ten teams involved in our CRACK IT programme who have produced 3Rs focused outputs that include prototypes, products and services.