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NC3Rs: National Centre for the Replacement Refinement & Reduction of Animals in Research

CRACK IT Challenge webinar: An in vitro model of the human osteoarthritic joint


Registration Details

Event date and time
Decorative image representing osteoarthritis

This CRACK IT Challenge webinar will focus on the development of a 3D osteoarthritis (OA) model of cartilage for preclinical testing of novel therapeutics. Developed through the Osteo-Chip CRACK IT Challenge sponsored by GSK and co-funded by Versus Arthritis and EPSRC, Alcyomics have designed the platform to model the biomarkers and molecular characteristics of cartilage damage seen in arthritis when injury is introduced.

Register via Zoom

The 3D in vitro model aims to overcome the limitations of in vivo models frequently used in the investigation of treatments for OA. Animal models can be highly variable, making reproducibility difficult, and models of joint disruption can cause high levels of chronic pain. The welfare concerns, long duration, limited translation to human disease and the significant cost of whole animal models mean there is a critical need for alternative assays.

Alcyomics have recently been awarded Business Growth Scheme funding from the NC3Rs to commercialise their OA platform, read their press release for more information.

This webinar is free to attend and will provide further insight into the OA model and its applications. You will hear from the product developers and there will also be an opportunity to ask questions to the speakers after the webinar presentation.

Speaker Bios 

Anne Dickinson, Alcyomics: Anne Dickinson is CEO of Alcyomics, established in 2007, providing unique non-animal non-artificial human based in vitro assays that transform drug development by enabling early and accurate identification of safe and efficacious compounds. Anne is also Emeritia Professor of Translational and Clinical Medicine at Newcastle University and has over 30 years’ research on haematopoietic stem cell transplantation and Graft versus Host Disease (GvHD).

Kenny Dalgarno, Newcastle University: Kenny Dalgarno is Professor of Manufacturing Engineering at Newcastle University and leads the Newcastle University Centre for Biomedical Engineering.  His current research focuses on bioprinting and biofabrication, developing innovative ways of processing biomaterials and biological materials in order to create in vitro tissues for drug testing and regenerative medicine.

Mahid Ahmed, Alcyomics: Mahid is a biomedical scientist and tissue engineer with expertise in bioprinting and 3D cell culture with previously experience of developing bioprinted human skin equivalents for in-vitro drug testing.



The Osteo-Chip Challenge, sponsored by GSK and co-funded by Versus Arthritis and EPSRC and launched in 2016, was a Two Phase Challenge that aimed to develop an in vitro model to recapitulate the human osteoarthritic joint for the research and drug development for OA. More information about the Osteo-Chip Challenge, Alcyomics and the OA model can be found on the NC3Rs Innovation Platform.

Certificates of attendance are available on request only to registered participants attending through their unique Zoom link.