![Blue pipette tips](/sites/default/files/styles/right_column_image/public/2021-08/Blue%20pipette%20tips.jpg?itok=3IhaOhQ4)
612 results
![Blue pipette tips](/sites/default/files/styles/right_column_image/public/2021-08/Blue%20pipette%20tips.jpg?itok=3IhaOhQ4)
With a decade of NC3Rs funding, scientists at the University of Birmingham have developed the first mature bone organotypic model, then systematically adapted and modified it to replace the use of rodents across a range of therapeutic areas involving the study of bone growth and regeneration.
Professor Anthony Chalmers and Co-Investigator Dr Natividad Gomez-Roman have further developed a 3D human cell culture model replacing the use of mice to evaluate and screen treatments for Glioblastoma (GBM).
![A group of researchers stand smiling on a sunny day after having paused on a bike ride.](/sites/default/files/styles/image_16_9/public/2023-12/Anthony%20Chalmers%20research%20group.jpg?itok=55uQtomU)
![Dr Carina Dunlop](/sites/default/files/styles/right_column_image/public/2023-12/Carina%20Dunlop_0.jpg?itok=evPdr5H7)
![Dr Pierre-Alexis Mouthuy](/sites/default/files/styles/right_column_image/public/2023-12/Pierre-Alexis%20Mouthuy.jpeg?itok=mQunz5Ik)
Dr Alan Harper and NC3Rs-BHF PhD student Jacob Ranjbar have developed an artificial human blood vessel to study blood clotting in vitro and replace the use of mice in thrombosis research. They have successfully disseminated the model to the thrombosis community, including for new applications within cardiovascular research.
![Portrait of Dr Alan Harper and Dr Jacob Ranjbar](/sites/default/files/styles/image_16_9/public/2023-12/Alan%20and%20Jacob%20headshots.png?itok=JZ7g9B54)
Dr Frank McCaughan and student, Dr Phil Barry, miniaturised a human cell-based model of early-stage lung cancer enabling the assay to replace some drug screening experiments using mice.
![Dr Frank McCaughan and two other speakers stand by a Pint of Science banner](/sites/default/files/styles/image_16_9/public/2023-12/Frank%20Pint%20of%20Science.jpg?h=39052301&itok=97SDneSq)
![Dr Richard van Arkel](/sites/default/files/styles/right_column_image/public/2023-12/Richard%20Van%20Arkel.jpg?itok=UIfazSlD)
![Dr Gowsihan Poologasundarampillai](/sites/default/files/styles/right_column_image/public/2023-11/Gowishan%20Poologasundarampillai.jpg?itok=u0_aoo11)
![Dr Peter Rugg-Gunn](/sites/default/files/styles/right_column_image/public/2023-11/Peter%20Rugg-Gunn_0.jpg?itok=1OJkGdO4)
![Dr Inês Cebola](/sites/default/files/styles/right_column_image/public/2023-11/CEBOLA%2C%20Ines%2024.10.2019%201_0.jpeg?itok=WA4nxi_V)
![Dr Anna Krasnodembskaya](/sites/default/files/styles/right_column_image/public/2023-11/Anna%20Krasnodembskaya.jpg?itok=kcC59Ixo)
![Headshot of Dr Michael Colman](/sites/default/files/styles/right_column_image/public/2023-11/Michael%20Colman.png?itok=EbBcEt5t)
![Headshot of Dr Gabriel Galea](/sites/default/files/styles/right_column_image/public/2023-11/Gabriel%20Galea.jpg?itok=wNogTo9X)
![Icons representing questions and answers within two speech bubbles](/sites/default/files/styles/right_column_image/public/2022-03/survey-for-website.png?itok=pJ0ClDaW)
![Needle in a vial of vaccine](/sites/default/files/styles/project_header/public/2022-04/vaccine%20needle%20injection.jpg?itok=yy_NKTZo)
Professor Cathy Merry has developed synthetic hydrogels that support 3D culture for multiple cell types and used NC3Rs funding to support their application across multiple scientific disciplines.
![Headshot of Professor Cathy Merry](/sites/default/files/styles/image_16_9/public/2021-08/Cathy%20Merry%20cropped.png?itok=UhzfKNPj)
Dr Karl Butterworth and PhD Student Dr Kathryn Brown have applied high precision cancer radiotherapy techniques used to treat human patients to improve the reproducibility and translatability of preclinical animal trials.
Dr Paola Campagnolo has used NC3Rs funding from a Project grant and a Skills and Knowledge Transfer award to develop an ex vivo model of the epicardium to replace the use of mice for high throughput screening of cardiac therapies in academia and industry.
![Dr Paola Campagnolo on the left with three colleagues on the right side of her in a laboratory](/sites/default/files/styles/image_16_9/public/2021-08/Paola.png?h=801bd34c&itok=IAeNrBPS)
![Six zebrafish in a tank](/sites/default/files/styles/right_column_image/public/2021-08/Zebrafish.jpg?itok=jRXVdGwO)