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Use the filters below to identify NC3Rs projects relevant to your work by R, topic, model or activity type. If you are looking for something specific, you can add keyword(s) into the search box.

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Topic

Model

Impact stories

686 results

Novel bioprinting technologies for engineering of compressible zonally stratified cartilage tissue for study of therapeutic interventions

Principal Investigator: Dr Katarzyna Pirog, Newcastle University

Strategic grant

A laboratory technician working with a syringe

Exploring the cardiotoxic effects of AZD5991 in human living myocardial slices

Principal Investigator: Professor Cesare Terracciano, Imperial College London

Strategic grant

A collection of test tubes containing coloured liquid

Co-developing dynamic human skin models for industrial validation and 3Rs impact

Principal Investigator: Professor Dame Molly Stevens, University of Oxford

Strategic grant

Gloved hands pipetting liquid into a 96 well plate

Human microphysiological model of chemotherapy-induced intestinal injury and repair for predictive toxicology

Principal Investigator: Dr Julia Mantaj, London South Bank University

Strategic grant

technician with microfluidic device LOC in microbiological lab

Developing human neutrophil-T-cell co-culture assays to refine off-target immunotoxicity testing of T-cell receptor-based therapeutics

Principal Investigator: Professor Felicity Gavins, Brunel University of London

Strategic grant

A cell culture plate containing pink liquid under a microscope. A gloved hand is holding the plate while another is pipetting liquid into it.

Advancing animal-free organ-on-a-chip models with PeptiMatrix

Principal Investigator: Dr Timothy Hopkins, Queen Mary University of London

Strategic grant

Organ on a chip system. The chip is being held against a blue background with orange tweezers causing the channels on the chip to have an orange hue.

Using large language models to make in vivo toxicity endpoints machine learning-ready

Principal Investigator: Dr Jessica Ewald, European Bioinformatics Institute

Strategic grant

Mathematician staring at maths problems on a whiteboard

Advanced 3D in vitro modelling of inflammatory bowel disease for evaluating biologic treatment efficacy and enabling computational analysis

Principal Investigator: Dr Paloma Ordóñez-Morán, University of Nottingham

Strategic grant

The arm of a researcher pipetting cell culture media into multi-well plates

Development of a vascularised glioblastoma tumour-on-chip for predictive, non-invasive chemotherapeutic evaluation

Principal Investigator: Professor Gareth Cave, Nottingham Trent University

Strategic grant

An organ-on-a-chip device being placed into the chamber of a machine

Developing a digital twin of 3D vascular systems to study haemorrhagic viral diseases

Principal Investigator: Dr Carina Dunlop, University College London

PhD Studentship

Mature human iPSC-derived atrial cardiomyocytes to replace animals in the study of atrial fibrillation

Principal Investigator: Dr Patrizia Camelliti, University of Surrey

PhD Studentship

A tissue culture hood containing media bottles and plates.

Development of 'human stroke-on-a-chip' model to replace rodent stroke models

Principal Investigator: Dr Hilary Carswell, University of Strathclyde

PhD Studentship

Developing patient derived tumour organoids to replace mouse models in understanding and improving anti-tumour T cell responses

Principal Investigator: Dr Emma Reeves, University of Southampton

PhD Studentship

Using a novel human 3D spheroid model to study mechanisms and therapeutics for vascular calcification

Principal Investigator: Professor Cathy Shanahan, King's College London

PhD Studentship

Using a defined 3D human organoid model to replace the use of animals in the screening and evaluation of treatments for prostate cancer

Principal Investigator: Dr Adriana Buskin, Newcastle University

PhD Studentship

Validating methods to cryopreserve, store and revive human precision cut tissue slices for disease modelling and drug testing

Principal Investigator: Professor Fiona Oakley, Newcastle University

PhD Studentship

Multi-omic analysis of human poor risk acute myeloid leukaemia to replace xenotransplantation assays and expand leukaemic stem cells

Principal Investigator: Dr William Grey, University of York

PhD Studentship

A scientist pipetting liquid into a microtube.

Combining machine learning and human skin explant models to harness beneficial skin microbes to treat atopic dermatitis

Principal Investigator: Dr Thomas Clarke, Imperial College London

PhD Studentship

Human sensory neuron and macrophage co-culture; developing a model to test agents capable of disrupting painful neuroimmune signalling

Principal Investigator: Dr Greg Weir, University of Glasgow

PhD Studentship

Integrated training and data sharing to accelerate adoption of 3Rs technology in trypanosome infection research

Principal Investigator: Dr Catarina Gadelha, University of Nottingham

Partnerships and impact awards