Genetically altered mice

Here we collate general information to help with the implementation of approaches to reduce and refine the use of genetically alteredĀ (GA) mice.

Guidance on re-establishing colonies after a pause (e.g. COVID-19 lockdown) with an emphasis on minimising the number of mice used.
Improving reproducibility and avoiding genetic mosaicism using CRISPR/Cas9 technology.
Ways to improve animal welfare.
A discussion on the possible impact of genetic drift on the integrity of the data from GA mouse studies.
Scientific and welfare reasons for reviewing neonate care .
Comparing the technical performances of background strains.
Links to mouse databases and resources to support good colony management.
Opportunities for reduction and refinement (downloads a PDF).
The importance of background strain.