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International 3Rs Prize now open for applications. £30k prize (£2k personal award) for outstanding science with demonstrable 3Rs impacts.

NC3Rs | 20 Years: Pioneering Better Science

Dr Helen Prior

Scientific Advisor - Pharmaceutical Development
Portrait of Dr Helen Prior

A former NC3Rs Programme Manager, Helen now provides scientific advice to the Toxicology and Regulatory Sciences team within the Science and Technology Group. 

View Helen's Office-led projects.

External roles

  • Board member of the Safety Pharmacology Society (2019-2020)
  • Secretary of the Safety Pharmacology Society (2017-2018)
  • Member of the scientific advisory panel for INSPIRE Horizon 2020 collaborative project (2019-2023)
  • Co-chair of the programme committee for the Safety Pharmacology Society 2021 annual meeting

NC3Rs publications

Prior H et al. (2021). Refining Procedures within Regulatory Toxicology Studies: Improving Animal Welfare and Data. Animals 11: 3057. doi: 10.3390/ani11113057

Namdari R et al. (2021). Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice. Regulatory Toxicology and Pharmacology 126: 105029. doi: 10.1016/j.yrtph.2021.105029

Prior H and Holbrook M (2021).  Strategies to encourage the adoption of social housing during cardiovascular telemetry recordings in non-rodents.  Journal of Pharmacological and Toxicological Methods 108: 106959.  doi: 10.1016/j.vascn.2021.106959   

Prior H et al. (2020). Justification for species selection for pharmaceutical toxicity studies. Toxicology Research 9: 758-770. doi: 10.1093/toxres/tfaa081

Prior H, et al. (2020).  Opportunities for use of one species for longer-term toxicology testing during drug development: a cross-industry evaluation.  Regulatory Toxicology and Pharmacology 113: 104624. doi: 10.1016/j.yrtph.2020.104624

Jackson SJ et al. (2019).  Neurofunctional test batteries in safety pharmacology – Current and emerging considerations for the drug development process.  Journal of Pharmacological and Toxicological Methods 100: 106602. doi: 10.1016/j.vascn.2019.106602

Prior H et al. (2019).  Integration of Consortia Recommendations for Justification of Animal Use Within Current and Future Drug Development Paradigms. International Journal of Toxicology 38: 319-325. doi: 10.1177/1091581819852922

Skinner M et al. (2019).  Social-housing and use of double-decker cages in rat telemetry studies.  Journal of Pharmacological and Toxicological Methods 96: 87-94 doi: 10.1016/j.vascn.2019.02.005

Prior H et al. (2019). Reflections on the progress towards non-animal methods for acute toxicity testing of chemicals.  Regulatory Toxicology and Pharmacology 102: 30-33. doi: 10.1016/j.yrtph.2018.12.008

Jackson S et al. (2018). The use of human tissue in safety assessment. Journal of Pharmacological and Toxicological Methods 93: 29 - 34 doi: 10.1016/j.vascn.2018.05.003

Prior H et al. (2018).  Reviewing the utility of two species in general toxicology related to drug development.  International Journal of Toxicology 37: 121-124. doi: 10.1177/1091581818760564

Prior H et al. (2017). Overview of 3Rs opportunities in drug discovery and development using non-human primates. Drug Discovery Today: Disease Models. 23: 11-16. doi: 10.1016/j.ddmod.2017.11.005

Sewell F et al. (2016). Opportunities to Apply the 3Rs in Safety Assessment Programs. ILAR Journal 57 (2): 234-245. doi: 10.1093/ilar/ilw024

Prior H et al. (2016). Social housing of non-rodents during cardiovascular recordings in safety pharmacology and toxicology studies. Journal of Pharmacological and Toxicological Methods 81: 75-87. doi: 10.1016/j.vascn.2016.03.004

For publications, see Helen's ResearchGate profile.


UK and European Registered Toxicologist (ERT)
Accredited since 2019

Diplomate in Safety Pharmacology (DSP)
Accreditated since 2013

PhD, Cardiovascular Pharmacology
University of Leeds 1994 – 1997
K+ channel subtypes and adenosine A2A receptors in rabbit renal arcuate artery