Grant holder information

Here we provide a summary of what can be expected from the NC3Rs as a funder, as well as the expectations we have for our grant holders. Please contact the NC3Rs funding team for further information.

Grant holder interactions | Post award amendments | Reporting requirements and evaluation | Publications and open access publishing |Terms and conditions | Policies | Further resources

Grant holder interactions

For the 3Rs impacts of a project to be fully realised, NC3Rs-funded work needs to be widely disseminated and adopted by the scientific community. We aim to support our grant holders in these activities as much as possible, and we will arrange meetings to discuss a grant during the lifetime of the award. The main points of interaction are:

Introductory phone call (start of award)

The funding team Programme Manager will arrange to speak with a grant holder within the first two months of their award beginning.

Grant holder visit (mid-point of award) 

Halfway through their award, the funding team Programme Manger will send grant holders a Progress Report Form to complete and organise a meeting to discuss progress made on the grant, any challenges encountered, as well as the support that the NC3Rs can provide. Our Board members often also attend these meetings.

Progress update by phone or visit (end of award)

We will call/visit within six months of the end of the award to discuss the outcomes and outputs of the project, as well as opportunities to achieve further 3Rs impact.

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Post-award amendments

Post award amendments, including extensions and changes to the project, should be first discussed with the NC3Rs funding team by emailing

Project extensions

The NC3Rs does not routinely extend awards, except for maternity leave, gaps in employment or staggered start dates. In exceptional circumstances, we may consider extending the grant.

The delays or shortfall must seriously threaten the delivery of a significant proportion of the science outlined in the original application. Applicants must be able to demonstrate the delays could not have been anticipated, were outside their control and every effort has already been made to mitigate them.

With the exception of multiple periods of maternity/paternity/sick leave, a grant will be allowed no more than one extension. If an extension has already been approved, further requests will not normally be considered. 

Requests for additional funds will only be considered in exceptional circumstances. 

Changes to an NC3Rs-funded project

Grant holders must inform and consult with the NC3Rs if there are any significant changes that may affect the progress or delivery of the project and its potential to realise a 3Rs impact. No substantive changes to the experimental design of a project involving the use of animals, which might affect the ethical characteristics of the award, are allowed without prior approval from the NC3Rs.

If a grant holder proposes to make significant changes to their NC3Rs-funded project, we reserve the right to request revised proposals for approval. Where significant changes are proposed, the NC3Rs may decide to make a new grant in place of the existing grant, or to revise, retain or terminate the existing grant.

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Reporting requirements and evaluation

Grant holders should report on the outputs and outcomes of the research we have funded on a regular basis, including after the lifetime of the award. In line with UKRI, we use Researchfish to collect this information, including an annual mandatory submission period. 

A summary of outputs and impacts as reported by our grant holders in the 2020 researchfish® submission period can be accessed here. Please note clicking this link will download a pdf file.


  • To showcase your impacts and achievements
  • To identify how we can use our expertise and networks to help maximise your impacts - both scientific and 3Rs
  • To answer parliamentary questions and to support funding bids for investment in the NC3Rs


  • Common outcomes - details of all outputs, outcomes and impacts arising from the grant
  • 3Rs question set - detailing the 3Rs impacts of the grant


  • Researchfish can be updated all year around 
  • Mandatory annual collection period (February to March) for the duration of the grant and up to five years after it has ended


  • PI is responsible for the submission, but can give access to other team members to help input information

Log-in details are provided by Researchfish Ltd. Researchers who do not report into Researchfish when requested to do so, or use the system inappropriately, may become ineligible to apply for future NC3Rs funding. Information in Researchfish should also be updated shortly before the grant is due to end. Failure to update within three months of the grant end date will result in financial and non-financial sanctions.

Previous Researchfish submission period summaries

A summary of outputs and impacts as reported by our grant holders in previous researchfish® submission periods. Please note clicking a link will download a pdf file.

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Publications and open access publishing

We want to help maximise the impact of your research, including any publications or other material arising from an NC3Rs award. We can only do this with appropriate notice, allowing time to prepare publicity material. Ideally, inform us pre-publication by emailing a PDF copy of your manuscript to

We also have the following expectations of publications arising from NC3Rs funding:

3Rs impacts 

It is a missed opportunity if publications from NC3Rs-funded grants are published without the 3Rs impacts being articulated. 

All publications arising from NC3Rs funding should:

  • Make reference to the 3Rs implications of the research, including in the abstract and the main body of the text
  • Be reported in accordance with the ARRIVE guidelines, taking into account the specific editorial policies of the journal concerned

3Rs methods

Grant holders must ensure that all outcomes of NC3Rs-funded research including the data, results, final conclusions and any other information relating to the research are published on a freely accessible platform in accordance with the RCUK policy on Open Access. All grant holders must ensure that the methodologies developed as part of NC3Rs-funded project(s) are published on the NC3Rs gateway or on another freely accessible platform.

Open access

We expect NC3Rs grant holders to disseminate their results by publishing in appropriate scientific journals, which are compliant with the UKRI open access of publications policy. The NC3Rs contribution to Article Processing Charges (APCs) will be paid for via the MRC contribution to the RCUK block grant. Any publication arising from NC3Rs-funded research should be deposited into Europe PubMed Central at the point of publication or within six months at the latest and included in your Researchfish grant record.

Open data

We follow UKRI policy and support the principles of the Concordat on Open Research Data, which recognises that research data should be made openly available for use by others wherever possible in a manner consistent with relevant legal, ethical, disciplinary and regulatory frameworks and norms, and with due regard to the cost involved.

Guidance text for acknowledging the NC3Rs

'We thank the National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) for funding this work ([insert grant number] to [insert author(s) initials]). Article processing charges were paid from the Medical Research Council contribution to the RCUK block grant to [insert name of institution].'

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Terms and Conditions

The terms and conditions of your NC3Rs grant will be set out in your award letter. For reference, the terms and conditions relevant to each grant type are as follows:

NC3Rs grant Terms and Conditions
Project grant

NC3Rs Terms and Conditions

UKRI Terms and Conditions

Skills and Knowledge Transfer grant

NC3Rs Terms and Conditions

UKRI Terms and Conditions


Joint CRUK-NC3Rs:

CRUK/NC3Rs Joint Award Terms and Conditions.

Training Fellowship

Training Fellowship Terms and Conditions

UKRI Terms and Conditions


NC3Rs Training Grant Terms and Conditions

Terms and Conditions of Research Council Training Grants


Joint BHF-NC3Rs:

BHF/NC3Rs Joint Award Terms and Conditions


Joint Unilever-NC3Rs:

Unilever/ NC3Rs Joint Award Terms and Conditions

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NC3Rs-funded researchers must also abide to the following guidance and guidelines:

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Further resources

Here we list a number of links to other pages of the NC3Rs website that may be helpful for our grant holders:

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