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International 3Rs Prize now open for applications. £30k prize (£2k personal award) for outstanding science with demonstrable 3Rs impacts.

NC3Rs | 20 Years: Pioneering Better Science
Impact story

Impact stories: Oncology and cardiovascular biology

Illustration showing the various organs that an organ-on-a-chip can model, including the retina, brain, heart, lungs, kidneys and intestines.

Showcasing our grant holders and how NC3Rs-funded research comes together to develop innovative new 3Rs tools and technologies that are pioneering better science.

Our latest three impact stories focus on oncology and cardiovascular biology, representing over £500k of investment from NC3Rs and The British Heart Foundation (BHF) to the University of Glasgow, University of Cambridge and Keele University.

Replacing mice and improving Glioblastoma outcomes

Professor Anthony Chalmers and Co-Investigator Dr Natividad Gomez-Roman have further developed a 3D human cell culture model replacing the use of mice to evaluate and screen treatments for Glioblastoma (GBM). Hear how developing this model has impacted their research and careers.

Forming clots in in vitro blood flow

Dr Alan Harper and NC3Rs-BHF PhD Student Jacob Ranjbar have developed an artificial human blood vessel to study blood clotting in vitro and replace the use of mice in thrombosis research. They have successfully disseminated the model to the thrombosis community, including for new applications within cardiovascular research. 

Screening chemoprevention strategies for squamous lung cancer 

Dr Frank McCaughan and student, Dr Phil Barry, miniaturised a human cell-based model of early-stage lung cancer enabling the assay to replace some drug screening experiments using mice.

We have an entirely new programme building lungs in the laboratory and this would not have happened without the confidence in in vitro human models engendered by our NC3Rs funding. 

Dr Frank McCaughan