Developing a stem-cell prostate organoid model - reducing global animal usage in prostate development and cancer studies Principal Investigator: Dr Adriana Buskin, Newcastle University Fellowship
Modelling of thrombus dynamics in a microfluidic 'vasculature' Principal Investigator: Dr Nicola Mutch, University of Aberdeen PhD Studentship
Long-term, self-maintaining primary 3D cultures of mouse and human epithelial tissues for reduction and replacement of animals in research Principal Investigator: Dr David Fernandez-Antoran, University of Cambridge Skills and Knowledge Transfer grant
The application of trabecular bone organoids to investigate mineral-sensing in skeletal physiology and disease Principal Investigator: Dr Alexandra Iordachescu, University of Birmingham Skills and Knowledge Transfer grant
Characterisation of Galleria mellonella innate immune response to Mycobacterium tuberculosis infection Principal Investigator: Dr Masanori Asai, Imperial College London Fellowship
Refinement of pre-exposure programs to reduce the use of fish in proliferative kidney disease monitoring in aquaculture Principal Investigator: Dr Hanna Hartikainen, University of Nottingham PhD Studentship
Accelerating the uptake of non-animal derived antibodies Current contact: Dr Rachel Eyre, Office-led project
Exploring the role of matrix encapsulation on early developmental decisions using non-animal sourced hydrogels Principal Investigator: Professor Cathy Merry, University of Nottingham PhD Studentship
3D patient-derived organoids: A viable and complementary model to study neural system dysfunction in Alzheimer's Disease Principal Investigator: Dr Marc Busche, University College London PhD Studentship
Efficacy of artificial imprinted antibodies in driving unwarranted immune responses Principal Investigator: Dr Shoba Amarnath, Newcastle University PhD Studentship
Human stem cell models of de novo tumorigenesis to replace the use of animals for the study of cancer initiation Principal Investigator: Dr Cinzia Allegrucci, University of Nottingham PhD Studentship
Defining drug delivery into and across the oral mucosa using a tissue engineering and mathematical modelling approach Principal Investigator: Professor Craig Murdoch, University of Sheffield Project grant
Reducing and replacing the animal cost of functional genetics in African trypanosomiasis Principal Investigator: Dr Catarina Gadelha, University of Nottingham Project grant
Preclinical Radiomics: A novel approach linking imaging with biological outcomes in mouse models Principal Investigator: Dr Kathryn Brown, Queen's University Belfast Fellowship
Validation of an in vitro humanised 3D haematopoietic system to investigate haematological malignancies Principal Investigator: Professor Helen Wheadon, University of Glasgow Project grant
Refinement of tickling protocols to improve positive animal welfare in laboratory rats Principal Investigator: Professor Alistair Lawrence, Scotland’s Rural College Project grant
Establishing Drosophila melanogaster as part of the pre-clinical pipeline for anti-metastatic cancer drug discovery Principal Investigator: Dr Kyra Campbell, University of Sheffield Project grant
Transfer of an in vitro model for the evaluation of anticoccidial compounds Principal Investigator: Dr Virginia Marugan-Hernandez, Royal Veterinary College Skills and Knowledge Transfer grant
Replacement of animal use in measuring cardiomyocyte response to drug safety profiling using a novel NMR metabolomics technology Principal Investigator: Dr Rachel Oldershaw, University of Liverpool PhD Studentship